ectopic pregnancy pain location


Identification of risk factors can raise the index of suspicion and lend significance to otherwise minor physical findings. Ectopic pregnancy, which is also known as tubal pregnancy or eccyesis is an abnormality of pregnancy where the foetus is not implanted inside the uterus but in some other location outside of it. An ectopic pregnancy and significant pain An ectopic pregnancy with an adnexal mass of 35 mm or larger An ectopic pregnancy with a fetal heartbeat visible on an ultrasound scan An ectopic pregnancy and a serum βHCG level of 5000 IU/litre or more In the presence of a haemodynamically unstable patient the quickest route for achieving et al. 25. Sexually transmitted diseases, pelvic inflammatory disease, and infertility: an epidemiologic update. In a normal pregnancy, the fertilized egg moves from the fallopian tube into the uterus, where the pregnancy develops. Stenman UH, Bisits A, Sexually transmitted diseases, pelvic inflammatory disease, and infertility: an epidemiologic update. 1-3 It is a common cause of morbidity and occasionally of mortality in women of reproductive age. 1990;3:125–8. Some clinicians continue to find progesterone determinations useful. Core EM is dedicated to bringing Emergency Providers all things core content Emergency Medicine. Many pregnant women, experience both the symptoms of vaginal bleeding as well as pain in the abdomen. What is an ectopic pregnancy? PMID: 17161083, Rana P et al. Once pregnancy is confirmed with a positive hCG, determining the location of the pregnancy with trans-vaginal ultrasound (TVUS) as either intra-uterine or ectopic is . Murthy HM, Obruca A, Van der Veen F, Aiman EJ, These symptoms are common in ectopic pregnancy. Gopal M, Obstet Gynecol Surv 2013;68:571. Aronson MD. For example, subtle changes in vital signs, such as mild tachycardia or lower than usual blood pressure, should prompt further investigation. Mol BW, Acta Obstet Gynecol Scand. The location, nature, and severity of pain with ectopic pregnancy may be pelvic or abdominal, unilateral or bilateral, localized, dull, sharp, cramping, intermittent or continuous. Pain may also spread to the shoulder, in case of bleeding into the abdomen. Copyright © 2000 by the American Academy of Family Physicians. A review. Previous ectopic pregnancy becomes a more significant risk factor with each successive occurrence. Atrash HK, 2017;69:241-250.e20. N Engl J Med. In ectopic pregnancy the levels are usually lower and rise more slowly. Ultrasound Obstet Gynecol 2005; 26:770. Tuomala RE, Cigarette smoking as a risk factor for ectopic pregnancy. One explanation for the mistaken association of IUDs with ectopic pregnancy may be that when an IUD is present, ectopic pregnancy occurs more often than intrauterine pregnancy.1,8 Simply because IUDs are more effective in preventing intrauterine pregnancy than ectopic pregnancy, implantation is more likely to occur in an ectopic location. Karacan M, Hassid J, If retention of the intrauterine gestation is desired, the ectopic pregnancy must be treated surgically.1,12, Interested in AAFP membership? An ectopic pregnancy can lead to life-threatening bleeding if it ruptures. primary amenorrhea. Ylostalo P. As the ectopic pregnancy progresses, abdominal pain may become severe and sharp. Tuomala RE, Cates W Jr, 7. Abbott J, Long CA, The diagnosis of ectopic pregnancy may sometimes be difficult, and symptoms may occur from as early as 4 weeks pregnant and up to 12 weeks or even later. Sharp abdominal cramps. pain in the lower abdomen. et al. 28. Stovall TG, Kalogirou D, Ankum WM, Mascha EJ, Abdominal pregnancy. Mateer JR, Ectopic pregnancy is a pregnancy that develops outside the womb (uterus). Some ectopic pregnancies detected today, for instance, would have spontaneously resolved without detection or intervention in the past. Fertil Steril. During ectopic pregnancy, this pain gives you a severe, sharp and a very strange kind of a sensation. The cause of this pain is due to the stirring up of the nerve called phrenic. Goldberg JM, Braffman BH, 9. Ectopic pregnancy is defined as implantation of a fertilized egg outside the uterine cavity. To see the full article, log in or purchase access. An ectopic . History of in utero exposure to diethylstilbestrol, In the general population, pelvic inflammatory disease is the most common risk factor for ectopic pregnancy. Sadek AL, Ectopic pregnancy and miscarriage: Evidence review for Diagnostic accuracy of ultrasound features for tubal ectopic pregnancy FINAL [April 2019] 6 o Haemoperitoneum o Free blood in the pelvis Reference tests • Surgical/histological confirmation of ectopic pregnancy • Confirmation of ectopic pregnancy on follow up ultrasound scan A systematic review of single-dose intramuscular methotrexate for the treatment of ectopic pregnancy. Cigarette smoking as a risk factor for ectopic pregnancy. Others: Appendicitis, cystitis, obstructed viscus, perforated viscus, pyelonephritis, vascular hemorrhage/ischemia. Gopal M, Don't miss a single issue. Mohla G, ACEP Clinical Policies Subcommittee (Writing Committee) on Early Pregnancy et al. You can also apply a cold pack to your shoulder for about 10 minutes as this will provide some relief. 2009;361:379-387. One study found that β-hCG levels higher than 1,500 mIU per mL are associated with a much higher risk of treatment failure.29 The same study also showed that patients with 3 -hCG levels higher than 5,000 mIU per mL (5,000 IU per L) usually do not respond to methotrexate therapy. The fallopian tube is . Surveillance for ectopic pregnancy—United States, 1970–1989. Kuligowska E, The success rate increases to 84 to 94 percent with the addition of a second single dose.31,32, Low-dose methotrexate regimens have been found to be no better than placebo.33. experience pain and/or bleeding in early pregnancy. 1996;88:775–8. Marshall B, Always consider the diagnosis of an ectopic pregnancy in any woman of child bearing age presenting with abdominal pain, vaginal bleeding, and missed period, Hemodynamically unstable patients need rapid diagnosis and stabilizing treatment, Involve consulting services early on in management course. Lancet. Goldner TE, A. Key to the diagnosis is determination of the presence or absence of an intrauterine gestational sac correlated with quantitative serum beta-subunit hCG (ß-hCG) levels. Surveillance for ectopic pregnancy—United States, 1970–1989. Corsan GH, Cates W Jr, Stovall TG, Obstet Gynecol. Norwalk, Conn.: Appleton & Lange, 1995:425–36. Pelvic inflammatory disease (PID), which is a female complication usually from sexually transmitted infections, may also cause suprapubic pain. J Trauma 2011;70:398. The most common location for ectopic pregnancy to occur is in one of the fallopian tubes. et al. Severe bleeding causes fainting, rapid heart rate and even shock. Ectopic pregnancy. Lancet. Thorburn J, Medical management of tubal pregnancy. Single-dose methotrexate: an expanded clinical trial. You may experience pain when passing urine or stools. Emmans LS, Ectopic pregnancy: Visualized ectopic pregnancy, with yolk sac or fetal pole outside the uterus. Ectopic Pregnancy on US (Case courtesy of A.Prof Frank Gaillard, Radiopaedia.org. Case reports indicate that viable abdominal ectopic pregnancies may be discovered at cesarean section, albeit rarely.13. Address correspondence to Josie L. Tenore, M.D., S.M., Glenbrook Family Care Center, 2050 Pfingsten Rd., Suite 200, Glenview, IL 60025. Methotrexate inhibits the synthesis of purines and pyrimidines. Gregoriou O, 2014 Mar;29(3):441-7. doi: 10.1093/humrep/det450. 1995;40:525–8. With one previous ectopic pregnancy treated by linear salpingostomy, the recurrence rate ranges from 15 to 20 percent, depending on the integrity of the contralateral tube.1,9 Two previous ectopic pregnancies increase the risk of recurrence to 32 percent, although an intervening intrauterine pregnancy lowers this rate.1,10, Endometriosis, tubal surgery and pelvic surgery result in pelvic and tubal adhesions and abnormal tubal function. PMID: 17377896, Parks JK et al. This type of ectopic pregnancy is called a tubal pregnancy. However, in other instances, it can attach to the ovary, cesarean section scar, cervix or even the abdomen. Obstet Gynecol Surv 2013;68:571. This is known as a rupture. Click below to contact us or find us on Twitter, Facebook or Google+. The advantages of direct injection include delivery of a higher concentration of active agent to the involved tissue, as well as fewer systemic toxic effects. When the results came in they didn't surprise anyone: no pregnancy tissue in my uterus. Coleman BG, Clinical management guidelines for obstetrician-gynecologists. 1 These women are at risk for complications, such as organ rupture with massive bleeding, risks related to treatment, recurrent ectopic pregnancy, and future infertility. Abdominal And Pelvic Pain. In: Operative obstetrics. Conservative versus radical surgery for tubal pregnancy. Neisseria gonorrhoeae, Chlamydia trachomatis, Criteria for the Use of Methotrexate (Rheumatrex) in Patients with Ectopic Pregnancy, Address correspondence to Josie L. Tenore, M.D., S.M., Glenbrook Family Care Center, 2050 Pfingsten Rd., Suite 200, Glenview, IL 60025. In the UK, 1 in 90 pregnancies (just over 1%) is an ectopic pregnancy. 24. Engelsbel S, Following assessment If early pregnancy bleeding or pain: Refer to the following guideline sections within this document: Bleeding (Early Pregnancy) Algorithm Successful treatment of a heterotopic pregnancy by sonographically guided instillation of hyperosmolar glucose. Egarter C, What Does Ectopic Pregnancy Pain Feel Like? In: Operative obstetrics. Cigarette smoking is known to affect ciliary action in the nasopharynx and respiratory tract. It often begins as a colicky abdominal or pelvic pain that is localized to one side as the pregnancy distends the fallopian tube. Diagnostic studies used in the evaluation of suspected ectopic pregnancy. Lehner R, In an ampullary ectopic pregnancy, a linear salpingostomy is performed, and the incision is then left to heal by secondary intent (Figure 4). Suggestions on how we can improve the site? Want to use this article elsewhere? Lundorff P, In Europe and the United States, this condition occurs in one of 2,600 pregnancies.34 With fertility treatments, the incidence of heterotopic pregnancy increases to as high as 3 percent.34 Heterotopic pregnancy is extremely difficult to diagnose, and 50 percent of cases are identified only after tubal rupture. PMID: Lipscomb GH. 14. Presumed ectopic pregnancy: Pregnancy where location has not been identified but is suspicious for ectopic; e.g. A ruptured ectopic pregnancy is a true medical emergency. Buster JE, Mortimer L. Thus an early YSG is suggested in most of the cases. Whitworth NS, Is maternal serum creatinine kinase actually a marker for early diagnosis of ectopic pregnancy? Benifla JL, 1983;32SS0119–21. Copyright © 2020 American Academy of Family Physicians.  All rights Reserved. PMID: 23921671, American Institute of Ultrasound in Medicine, ACEP. 1998;46:80–3. Common side effects include nausea and vomiting, urinary frequency and mild diarrhea. ectopic pregnancy, an empty intrauterine sac may be a pseudo sac in a woman with an ectopic pregnancy. Sac location - atypical location of the gestational sac in relation to the endometrial cavity should be reported. Am J Emerg Med. Pisarska MD, 1997;350:774–9. Need to comply with treatment and follow up, Patients with ectopic pregnancy may be discharged after administration of methotrexate, Hemodynamically stable patients may be discharged, Ecoptic pregnancy is the leading cause of 1, Rule Out Ectopic in the Emergency Department. Anandakumar C, Clinical value of creatinine kinase in the diagnosis of ectopic pregnancy. Clausen I. Shoulder pain. Thus, it interferes with DNA synthesis and cell multiplication. Serum progesterone and endovaginal sonography by emergency physicians in the evaluation of ectopic pregnancy. Bacquet K, While most people make a good recovery from an ectopic . Although past treatment consisted of an open laparotomy and salpingectomy, current laparoscopic techniques for unruptured ectopic pregnancy emphasize tubal preservation. 15. When the pregnancy is located in the isthmic portion of the fallopian tube, that segment is excised, and the two ends are reanastamosed under microscopic guidance at a later date. Treating the Ectopic Pregnancy: Methotrexate. The most studied of these agents is methotrexate, a folic acid antagonist that is metabolized in the liver and excreted in the kidney. Whitworth NS, Medical therapy for ectopic pregnancy. Lowenstein SR. Ectopic pregnancy: prospective study with improved diagnostic accuracy. 32. Weakness and shivering. Thus ectopic pregnancy is almost always accompanied with vomiting and diarrhoea. Ectopic pregnancy: ten common pitfalls in diagnosis. • Ectopic pregnancy - implantation occurs in a site other than the endometrial . Emergency department crystalloid resuscitation of 1.5 L or more is associated with increased mortality in elderly and nonelderly trauma patients. Thus any reproductive-age woman presenting with abdominal pain, pelvic pain, hemodynamic instability, or abnormal vaginal bleeding should have a pregnancy test. Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Arch Gynecol Obstet. Ectopic Location (Arleo 2014) Greater than 95% of extrauterine implantations occur in the fallopian tube. Strohmer H, Data on age, gravidity, parity, EP risk, amenorrhea duration, abdominal pain presence and location, β-human . Beral V, Bright DA, Falcone T, 1993;42:73–85. As the fertilized egg grows, it will eventually rupture (break open) the organ . J Ultrasound Med 2014;33:2047. Lundorff P, A pregnancy of unknown location (PUL) is when the woman has a positive pregnancy test and there is no evidence of pregnancy on the ultrasound scan. The most common location for an ectopic pregnancy is the Fallopian tube. Arheart KL, Am Fam Physician. 2000 Feb 15;61(4):1080-1088. Clin Imaging. If the test is positive, she should be considered to have an ectopic pregnancy until proved otherwise. The medication is given by injection. Currently, laparotomy is the preferred technique when the patient is hemodynamically unstable, the surgeon has not been trained in laparoscopy, physical facilities and supplies to perform laparoscopic surgery are lacking or technical barriers to laparoscopy are present. No pain or tenderness attributed to the ectopic Low/falling hCG levels (usually well below 1,000 IU/l) Ultrasound findings are inconclusive (i.e. Rectal pressure. et al. Ramchandani P, In: Operative obstetrics. Regardless of the treatment approach (expectant, medical or surgical), the β-hCG level should be followed until it becomes undetectable or decreases to less than 5 mIU per mL. The pain is felt while lying down and exact location of the pain cannot be comprehended. Ectopic pregnancy—United States, 1990–1992. Any mechanism that interferes with the normal function of the fallopian tube during this process increases the risk of ectopic pregnancy. J Ultrasound Med 2014;33:2047. A ruptured fallopian tube can cause life-threatening internal bleeding. In such cases repeated blood tests are done to measure the pregnancy. Findings such as hypotension and marked abdominal tenderness with guarding and rebound tenderness suggest a leaking or ruptured ectopic pregnancy. This accounts for the drug's effect on trophoblastic tissue, as well as its side effects on the buccal and intestinal mucosa, urinary bladder, bone marrow and skin. This kind of pain should not be associated with any similar pains of pregnancy as it happens only during ectopic cases. Figures 3 and 4 from Charles Miller, M.D., Advanced Institute of Fertility and Minimally Invasive Surgery, Arlington Heights, Ill. 1. A study of risk factors for ruptured tubal ectopic pregnancy. This regimen appears to be 82 to 86 percent effective in resolving ectopic pregnancy.30 Rates of subsequent fertility and tubal patency are comparable to those for conservative surgical management.30, Single-dose regimens have had a success rate of 71 percent. Korhonen J, Clin Imaging. Abdominal cramps with immense pain! Bossuyt PM, Clinical Policy: Critical Issues in the Initial Evaluation and Management of Patients Presenting to the Emergency Department in Early Pregnancy. Ultrasound Obstet . 27. Kendrick JS, - PAIN:- most constant feature in 95% pt - variable in severity and nature - AMENORRHOEA:- 60-80% of pt - there may be delayed period or slight spotting at the time of expected menses. Nodine CF, Semiquantitative urine testing is being evaluated and may provide a cost-effective alternative to serum β-hCG testing.19, Historically, serum progesterone levels were obtained concurrently with β-hCG levels. 26. Engelsbel S, Greater awareness of risk factors and . An ectopic pregnancy is a pregnancy that implants outside the endometrial cavity. Low-dose oral methotrexate with expectant management of ectopic pregnancy. The pain may be described as sharp, dull, or crampy. 2014;38:763-70. Epidemiol Rev. The effect of cigarette smoking, Chlamydia trachomatis infection, and vaginal douching on ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. PMID: Barnhart KT. It is preferred only in patients with uncontrolled bleeding, extensive tubal damage or recurrent ectopic pregnancy in the same tube. 1998;351:1115–20. 1998;7:459–63. The risk is as h. From the case rID: 46956), Heterotopic Pregnancy (Ultrasound Image Gallery), EM Updates: Rule Out Ectopic in the Emergency Department, EM: RAP: C3- Frist Trimester Vaginal Bleeding, ACEP Clinical Policies Subcommittee (Writing Committee) on Early Pregnancy et al. Kuligowska E, eventually rupture (at 6-16wks) or involute • Early symptoms/signs = pelvic pain, vaginal bleeding, cervical motion tenderness • Syncope or hemorrhagic shock can occur with rupture . 1994;170:1822–5. 1995;74:293–6. First-trimester rapid semiquantitative assay for urine pregnanediol glucuronide predicts gestational outcome with the same diagnostic accuracy as serial human chorionic gonadotropin measurements. Schiotz HA. The drug is given as an injection. (, Patient’s typically present 6-8 weeks after the last normal menstrual period, Diaphragmatic irritation from free blood in the peritoneal space may present as shoulder pain, Referred neck or rectal pain are reported, Vagal stimulation from intra-peritoneal blood can present as hypotension and bradycardia, OB/GYN conditions: Spontaneous abortion (of normal IUP), septic abortion, early normal IUP, ovarian cyst, ovarian/fallopian torsion, necrotic myoma, PID/TOA. Repeated visits to the hospital are essential (for blood Hum Reprod. Ectopic pregnancy is a complication of pregnancy in which the embryo attaches outside the uterus. Felchtinger W. Systemic hypotension is a late marker of shock after trauma: a validation study of ATLS principles in a large national sample. Corsan GH, 3. As the fertilized egg grows, it will eventually rupture (break open) the organ . In: Operative obstetrics. 8. I had a confirmed diagnosis of an ectopic or in my case a pregnancy of unknown location (a rare type of . Combined chemotherapy in the medical management of tubal pregnancy. Sometimes, the mother can go into shock in case of heavy internal bleeding. Hankins GD, Clark SL, Cunningham FG, Gilstrap LC. Valley VT, 1992;79:85–90. Parker J, When an ectopic pregnancy ruptures, women often have abdominal pain and vaginal bleeding, which, if not treated, can be fatal. Goldberg JM, The pain may be described as sharp, dull, or crampy. Kemmann E. Falconi LL, Am J Obstet Gynecol. Bisits A, Hogue CJ. Suspected ectopic pregnancy. 20. Clinical diagnosis and treatment of ectopic pregnancy. Parker J, The author thanks the following for their assistance in the preparation and review of the manuscript: Mitchell King, M.D., program director for the Department of Family Medicine, Northwestern University Medical School, Chicago; Martin Lipsky, M.D., chairman of the Department of Family Medicine, Northwestern University Medical School; and Daved Shanks, M.B.A. The evaluation may include a combination of determination of urine and serum human chorionic gonadotropin (hCG) levels, serum progesterone levels, ultrasonography, culdocentesis and laparoscopy. PMID: 21307740, Lipscomb GH. PMID: Samal SK, Rathod S. Cervical ectopic pregnancy. Obstet Gynecol 2004;103:1218. The shoulder tip pain during ectopic pregnancy is a severe associated symptom that is caused by triggering of a particular nerve. Sadek AL, Greater than 95% of extrauterine implantations occur in the fallopian tube. Kalogirou D, Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. The literature provides a wide range of sensitivities and specificities for transvaginal ultrasonography in the detection of ectopic pregnancy. 2009;361:379-387. Signs of a ruptured fallopian tube are: sudden, severe, sharp pain. Ectopic pregnancy. ACOG practice bulletin no. If attached to the abdomen, the danger of complications is significantly increased. If an ectopic pregnancy is left to develop, there is a risk that the fertilised egg could continue to grow and cause the fallopian tube to split open (rupture), which can cause life-threatening internal bleeding. Physical findings include a normal or slightly enlarged uterus, pelvic pain with movement of the cervix and a palpable adnexal mass. location of the pregnancy may not be established with Carson SA, Eur J Obstet Gynecol Reprod Biol. Other chemical markers, such as creatine kinase16,17 and fetal fibronectin levels,18 have been investigated and rejected because of inadequate diagnostic sensitivity. PMID: American Institute of Ultrasound in Medicine, ACEP. In minimally symptomatic or hemodynamically stable patients, serial β-hCG levels can be followed. Weakness, dizziness, or fainting. 1998;5:309–13. Signs of a rupture include a combination of: a sharp, sudden and intense pain in your tummy. Lammes FB. Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. The yolk sac is the earliest structure to develop inside the gestational sac and is normally seen by 5 weeks and 5 days of pregnancy. This pain is felt exactly at the shoulder tip and not on any part of your neck or your back. Pain in your shoulder, neck, or rectum. Ahn YW. Falcone T, The symptoms of an ectopic pregnancy include vaginal bleeding, abdominal pain and absence of menstruation. PMID: 23793551, Samal SK, Rathod S. Cervical ectopic pregnancy. Obruca A, Reprints are not available from the author, The author thanks the following for their assistance in the preparation and review of the manuscript: Mitchell King, M.D., program director for the Department of Family Medicine, Northwestern University Medical School, Chicago; Martin Lipsky, M.D., chairman of the Department of Family Medicine, Northwestern University Medical School; and Daved Shanks, M.B.A. Hankins GD, Clark SL, Cunningham FG, Gilstrap LC. Fetal fibronectin as a marker to discriminate between ectopic and intrauterine pregnancies. Other treatment options include the use of methotrexate therapy for small, unruptured ectopic pregnancies in hemodynamically stable patients. Dinsmore BJ, Mortimer L. Ectopic pregnancy occurs at a rate of 19.7 cases per 1,000 pregnancies in North America and is a leading cause of maternal mortality in the first trimester. From the case rID: 8161), Definition: Embryo implantation outside of the endometrial cavity, Free Fluid in Morrison’s Pouch (AHC Media), Ectopic Pregnancy US (Case courtesy of Dr Maulik S Patel, Radiopaedia.org. Ectopic pregnancy is any pregnancy in which the fertilized ovum implants outside the intrauterine cavity. Rupturing leads to heavy bleeding and pain. 30. Husslein P, Medical therapy for ectopic pregnancy. A feeling of faintness, weakness or dizziness due to blood loss. Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. 1998;69:149–51. Risk factors include a history of pelvic inflammatory … Learn more. Washington, D.C.: American College of Obstetricians and Gynecologists, 1998. More serious symptoms of an ectopic pregnancy include: Sudden, severe or stabbing pain in the abdomen or pelvis (may come and go in sharp waves) Shoulder or neck pain. Heterotopic pregnancy: a reevaluation. 31. Am J Surg 2006; 192:727. However, some people experience symptoms that are similar to those found in gastroenteritis, also known as stomach flu, and miscarriage. Hogue CJ. aching pelvic pain. The mechanism can be anatomic (e.g., scarring that blocks transport of the egg) or functional (e.g., impaired tubal mobility). Since early ectopic pregnancy symptoms take after those of healthy pregnancy, those symptoms particular to an extrauterine pregnancy will often rise later, beginning around 6-8 weeks into a pregnancy. An ectopic pregnancy is extremely dangerous for the pregnant woman. 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