Effect of allopurinol on cardiovascular outcomes in hyperuricemic patients: a cohort study.
1995;25(1):119–25.Gimpel JA, Lahpor JR, van der Molen A-J, Damen J, Hitchcock JF. The World Health Organization estimates that, every year, MI accounts for 7.3 million deaths worldwide [This systematic review and meta-analysis was performed in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) statement [Citations from all four databases were pooled and screened by four independent reviewers (A.M., S.M, D.N. Serum uric acid and the renin-angiotensin system in hypertension. (1991) found that high-dose allopurinol administration significantly decreased ischaemic markers including aspartate transaminase, creatine kinase and lactate dehydrogenase in the postoperative period [There are a number of proposed mechanisms which could explain the cardioprotective effects of allopurinol [Interestingly, randomised controlled trials investigating the cardioprotective efficacy of allopurinol have largely focussed on operative settings such as CABG surgery. This meta-analysis was conducted using a fixed-effects model, and heterogeneity was assessed with the IOne thousand one hundred twenty-three citations were screened and only six studies satisfied the inclusion criterion.
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Prieto-Moure B, Lloris-Carsí JM, Belda-Antolí M, Toledo-Pereyra LH, Cejalvo-Lapeña D.J Invest Surg. By using this website, you agree to our Dermatologic.
2012;30(4):217–26.Guedes M, Esperança A, Pereira AC, Rego C. What is the effect on cardiovascular events of reducing hyperuricemia with allopurinol? Circulation. Initial searches yielded a total of 1123 citations.
The treatment effect of allopurinol was found to be greatest in the trial conducted by Rashid et al. Find out what health conditions may be a health risk when taken with allopurinol oral Grimaldi-Bensouda L, Alpérovitch A, Aubrun E, Danchin N, Rossignol M, Abenhaim L, et al. At 32 months, there …
Pharmacol Rev. Ann Thorac Surg.
An evidence-based review. J Clin Investig. 2009;6(7):e1000097.Minges KE, Zimmet P, Magliano DJ, Dunstan DW, Brown A, Shaw JE. Author information: (1)1Experimental Surgery, Universidad Católica de Valencia, Valencia, Spain.
Allopurinol is a xanthine oxidase inhibitor and antioxidant free radical scavenger which facilitates the protection of ischemic organs in part via this mechanism of action. Cardiovasc Ther. After removal of duplicate results, titles and abstracts were screened to identify studies eligible for full text review. Methods and Results: Cardiac surgery patients with hyperuricemia (n=141) were randomized to a febuxostat group or an allopurinol group. 1994;71(2):177–81.de Abajo FJ, Gil MJ, Rodríguez A, García-Poza P, Álvarez A, Bryant V, et al. Under these conditions, allopurinol diminishes the effect of inflammatory mediators during the ischemic inflammatory response. Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting. 2015;74(5):836–42.Singh JA, Yu S. Allopurinol reduces the risk of myocardial infarction (MI) in the elderly: a study of Medicare claims. J Hypertens. 1994;107(1):248–56.Castelli P, Condemi AM, Brambillasca C, Fundarò P, Botta M, Lemma M, et al. Author information: (1)Department of Surgery, University Hospital, Leiden, The Netherlands. Among patients undergoing CABG and cardiac valve replacement surgery, Tabayashi et al. Hypertension.
Biochem Mosc. The ischemic lesion generates a well-established inflammatory response with the subsequent production of inflammatory molecules characteristically present at the first stages of the injury. You can also search for this author in Further research is required to confirm these findings.Myocardial infarction (MI) is a common and frequently fatal endpoint of ischaemic heart disease. Allopurinol is known chemically as 1,5-dihydro-4 H-pyrazolo [3,4-d]pyrimidin-4-one.It is a xanthine oxidase inhibitor which is administered orally. General. 2015;101(9):679–85.