Asociality and social anxiety likely have multiple complex causes.This is an interesting take on SAD and serotonin.
Pro-psychotic amphetamines can temporarily relieve social anxiety in a handful of stimulant naive cohorts, that is until tolerance and toxicity sets in.Non-hallucinogenic 5-ht2a agonists, 5-ht1a full agonists, OXT at vasopressin 1a, NPS, anxiogenic ACTH releasing agents (w/feedback modulation), the glutamate and DA systems in general may or may not be worth investigating.
A study conducted by Uppsala University analyzed serotonin synthesis and reuptake in the brains of people with social anxiety. As I doubled the dosage of Paxil CR to 25 mg – I became more anxious and felt worse; at this point my serotonin level was likely too high to function as a teenager.As I’ve noted in a previous article, the nervous breakdown resulted in severe depression and anxiety for nearly 8 months. This is the main cause of an excessively high serotonin level. Thanks.How To Have a Frightfully Good Time At a Party (When You're Anxious) Neuroanatomical, neurotransmitter, genetic, epigenetic, nutritional, and social influences may interact to cause an individual to feel socially anxious. In I’m not alone in my experience either, there are many other anecdotes of individuals reporting that in cases of severe “fear-based” anxiety associated with somatic preoccupation (e.g. There is clear evidence that heightened levels of serotonin can exacerbate social anxiety in animals, as well as some people with social anxiety. I experience little noticeable effect on anxiety from SSRI antidepressants. The entire time I was on the drug, I felt as if I was chemically-enhanced to the point of being “high.”The pleasurable feeling associated with using Paxil CR at 12.5 mg was significant enough to help me make friends, engage in social events, and become one of the most popular kids at my school. For example, SSRIs are also known to restore prefrontal cortex response to emotional challenges, and alter blood flow in the insula and anterior cingulate cortex (ACC). In what a press release from Sweden’s Uppsala University called a “major leap forward” in understanding of mental disorders, a study in JAMA Psychiatry reported that, “Individuals with social phobia make too much serotonin.
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However, eventually the drug would stop working. I agree with you in that low serotonin levels are not the only cause of anxiety but can definitely contribute.There seems to be a contradiction in your brief article. It could also be speculated that the fear-signaling from the amygdala may be weaker than usual, meaning it triggers a fear-based response in social situations, but the weak signaling cannot be overruled by other regions because they never get the signal.It is known that social anxiety is incredibly more complex than serotonin. However, it’s going to take “baby steps” like this study to advance brain research and neuroscience.To add something else useful to the discussion (I didn’t mean to completely dismiss the premise earlier):Granted this is not an effect from reducing monoamine levels of 5-HT, but rather directly antagonizing receptors. It is also important to consider the fact that there may be significant individual variation in regards to the pathology of social anxiety disorder.
Data was collected over the course of approximately 10 years (from March 2002 to March 2012).PET scans allow researchers to track brain activity via the usage of a radioactive tracer. Your body and brain are complex systems in that they respond to environmental stimuli, nutrition, and genetic inputs. Though I agree it would not be safe to rest the entire cause of anxiety on 5-HT transmission alone.This is speculative, but a general trend in efficacy for SSRI’s may indicate the the human brain has increased tolerance to excessive serotonin and related functioning, as opposed to deficiencies in serotonin.
This research throws up some interesting ideas, and suggests that for some, too much serotonin can be a problem.