Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. If experienced, these tend to have a Less Severe expression. Proceeding from the visible surface towards the surface attached to the skin, these layers are:The active components of the transdermal system are estradiol and levonorgestrel. Some of the parent levonorgestrel also circulates as the 17β-sulfate. [see Use in Specific Populations (8.5), and Clinical Studies (14.6)][see Use in Specific Populations (8.5), and Clinical Studies (14.6)]Table 1: All Treatment Emergent Reactions Regardless of Relationship Reported at a Frequency of >3% with Climara Pro in the 1-year Endometrial Hyperplasia StudyTable 2: Summary of Mean Pharmacokinetic ParametersSummary of Mean (± SD) Pharmacokinetic Parameters Following a Single Application Summary of Mean (± SD) Pharmacokinetic Parameters (Week 4) Following Four Consecutive Weekly Applications of Climara Pro in 44 Healthy Postmenopausal WomenTable 3: Summary of Mean Daily Number of Moderate to Severe Hot Flushes-ITTTable 4: Summary of Mean Severity of Moderate to Severe Hot Flushes-ITTTable 5: Incidence of Endometrial Hyperplasia during Continuous Combined Treatment with Climara Pro, ITTTable 6: Mean Bone Mineral Density (Standard Deviation)Table 7: Relative and Absolute Risk Seen in the Estrogen Plus Progestin Substudy of WHI at an Average of 5.6 Years[hazard ratio (HR) 0.69 (95 percent CI, 0.44–1.07)]Table 8: Relative and Absolute Risk Seen in the Estrogen-Alone Substudy of WHI[see Warnings and Precautions (5.3), and Use in Specific Populations (Possible Serious Adverse Reactions with Estrogen Plus Progestin TherapyPossible Less Serious but Common Adverse Reactions with Estrogen plus Progestin TherapyWhat is the most important information I should know about Climara Pro (combinations of estrogen and a progestin)?Help reduce your chances of getting osteoporosis (thin weak bones)Do not use Climara Pro if you have had your uterus (womb) removed (hysterectomy).are allergic to Climara Pro or any of its ingredients What should I tell my healthcare provider before I use Climara Pro?Before you use Climara Pro, tell your healthcare provider if you:Tell your healthcare provider about all the medicines you takeFor detailed instructions, see the step-by-step instructions for using Climara Pro at the end of this Patient Information.the new patch must be applied to a different skin area of your lower abdomen or buttocks.Side effects are grouped by how serious they are and how often they happen when you are treated.Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:What can I do to lower my chances of a serious side effect with Climara Pro?How should I store and throw away used Climara Pro?KEEP CLIMARA PRO and all medicines out of the reach of children.General information about the safe and effective use of Climara Pro.Step 1: Pick the days you will change your Climara Pro.Step 2.
Statistically significant increases in risk for both DVT (26 versus 13 per 10,000 women-years) and PE (18 versus 8 per 10,000 women-years) were also demonstrated. Attempts to discontinue the medication should be made at 3 to 6 month intervals.Climara Pro 0.045 mg per day/0.015 mg per day applied to the skin once weekly.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drugs & Medications Climara Patch, Transdermal Weekly. In women with pre-existing hypertriglyceridemia, estrogen therapy may be associated with elevations of plasma triglycerides leading to pancreatitis. According to the predefined stopping rule, after an average follow-up of 5.6 years of treatment, the increased risk of invasive breast cancer and cardiovascular events exceeded the specified benefits included in the "global index". Women often experience withdrawal bleeding at the completion of the cycle. Discuss the use of grapefruit products with your doctor.heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;vomiting, jaundice (yellowing of the skin or eyes);high levels of calcium in your blood--nausea, vomiting, stomach pain, loss of appetite, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless.vaginal itching or discharge, breakthrough bleeding.This is not a complete list of side effects and others may occur. After an average follow-up of 4 years, 40 women in the CE plus MPA group and 21 women in the placebo group were diagnosed with probable dementia.