Spontaneous intestinal motility in both rats and dogs is reduced following oral dosing with 0.1 to 0.25 mg/kg. Respiration, pulse and blood pressure should be monitored, as in all cases of drug overdosage, although, in general, these effects have been minimal following chlordiazepoxide hydrochloride overdosage.While the signs and symptoms of Librax overdosage may be produced by either of its components, usually such symptoms will be overshadowed by the anticholinergic actions of clidinium bromide. The taming effect of chlordiazepoxide hydrochloride was further demonstrated in rats made vicious by lesions in the septal area of the brain. Librax also contains an anticholinergic /spasmolytic and is used to treat stomach ulcers, irritable bowel syndrome, and intestinal infections. Librax may also be used as adjunctive therapy in the treatment of peptic ulcer and in the treatment of the irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.Librax is contraindicated in the presence of glaucoma (since the anticholinergic component may produce some degree of mydriasis) and in patients with prostatic hypertrophy and benign bladder neck obstruction. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. In the first mating, no significant differences were noted between the control or the treated groups, with the exception of a slight decrease in the number of animals surviving during lactation among those receiving the highest dosage.
Your doctor may occasionally change your dose to make sure you get the best results. You can ask your pharmacist or healthcare provider for information about Librax that is written for health professionals.Librax is a trademark of Bausch Health Companies Inc. or its affiliates.© 2020 Bausch Health Companies Inc. or its affiliatesFor more information, go to bauschhealth.com or contact Bausch Health US, LLC at 1-800-321-4576.This Medication Guide has been approved by the U.S. Food and Drug Administration.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. On oral administration in mice, it proved an effective antisialagogue in preventing pilocarpine-induced salivation. Dialysis is of limited value. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. Because of the varied individual responses to tranquilizers and anticholinergics, the optimum dosage of Librax varies with the diagnosis and response of the individual patient. Take Librax exactly as it was prescribed for you. Administer physostigmine 0.5 to 2 mg at a rate of no more than 1 mg per minute. In general, the concomitant administration of Librax and other psychotropic agents is not recommended. You may report side effects to FDA at 1-800-FDA-1088.Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. However, in another study at 100 mg/kg daily there was noted a significant decrease in the fertilization rate and a marked decrease in the viability and body weight of offspring which may be attributable to sedative activity, thus resulting in lack of interest in mating and lessened maternal nursing and care of the young. The usual precautions are indicated when chlordiazepoxide hydrochloride is used in the treatment of anxiety states where there is any evidence of impending depression; it should be borne in mind that suicidal tendencies may be present and protective measures may be necessary. In the second mating, similar results were obtained except for a slight decrease in the number of pregnant females and in the percentage of offspring surviving until weaning.