His QTc peaked at 504 but, he remained in sinus rhythm. These "responders" tend to fit the criteria listed above (those with eating disorders, body set point malfunction and/or depression). Will other anti-depressants work just like Wellbutrin?Wellbutrin is considered unique among anti-depressants in that it is at LEAST weight neutral and at best usually helps with weight loss somewhat. Yes, calories do matter - but they take a backseat to the influence that powerful weight altering hormones such as Before we jump into how Wellbutrin helps with weight loss we need to discuss the basics:First off, Wellbutrin is a medication most commonly prescribed to treat depression, anxiety, and certain eating disorders. This study showed that various doses of Wellbutrin were very well tolerated and were associated with a 24-week weight loss of 7.2% and 10.1% based on dose. Just prior to arrival his girlfriend woke to find him sitting up against a wall in the bedroom with multiple empty bottles of bupropion XL. He was afebrile, mildly hypertensive and tachycardic, non-tachypneic, and saturating normally on room air. However, the dose is usually not more than 450 mg per day. Not everyone will achieve weight loss by using Wellbutrin, in fact, there is a chance it simply won't help you at all. Let's dig into how Wellbutrin helps with weight loss and determine if it's right for you (because it certainly doesn't work for everyone)... Just because a medication may help with weight loss doesn't mean it actually does a good job. As with any other weight loss medication (or weight loss therapy) I highly recommend against this strategy. Hopefully, you understand that weight gain has more to do with your metabolic and hormone function than it does with how many calories you are consuming. It should only be taken every 24 hours in the morning. Don’t miss out on this once in a lifetime chance to join your EM community online to learn, inspire, and connect during ACEP20 Unconventional. But why do we have such high variability between medications?This has to do with HOW weight gain occurs, and it's different for each person. Does this mean that you should run out and ask your Doctor to prescribe you Wellbutrin?While Wellbutrin MAY lead to weight loss it doesn't mean that everyone should use it. In the vast majority of cases, bupropion induced seizure is preceded by a prodrome with agitation, tremor, or hallucination occurring prior to seizure [7]. It's far better to use MULTIPLE therapies at once or to combine medications to get a synergistic effect. The second case involved a 16-year-old boy with a history of marijuana and alcohol use, that crushed and insufflated six 150 mg bupropion tablets resulting in generalized tonic-clonic seizure. He was discharged on the 3Initially investigated by Burroughs Wellcome in the 1970’s as a potential anti-depressant, bupropion is an N-Therapeutic doses of bupropion (150-300 mg daily) are generally well tolerated with the most common side effects being dry mouth and insomnia. Initially, 150 mg PO once daily in the morning; titrate after no less than 4 days to 150 mg PO twice daily if needed. Single doses of bupropion SR could not exceed 150 mg/dose. While Wellbutrin does provide potentially significant benefit - up to 10% weight loss over several months, it doesn't come without any side effects. If you notice an INCREASE in food cravings while taking Wellbutrin then it may not be worth continuing (if your sole purpose for using it is weight loss). Wellbutrin is an atypical anti-depressant in that it tends to help with not only depression but weight loss as well. These numbers may not sound great at first but you have to realize that this data stems from the use of Wellbutrin as monotherapy (meaning using Wellbutrin by itself). This effect may be mediating through excessive adrenaline (norepinephrine) levels, but it's not clear. Determining the dose you need is based on how you respond to Wellbutrin and if you experience any negative reactions while taking it. Also, Wellbutrin tends to work the best in a select subset of patients known as "responders". With that in mind let's talk about who SHOULD use weight loss and who will benefit the most from using this medication. We know Wellbutrin generally promotes hormone balance but it is possible that it may promote the excessive production of a stress hormone known as cortisol. Lastly, you can generally prevent many of these side effects by starting off with a low dose and titrating only when necessary. Max dose: 6 mg/kg/day PO, in divided doses. I have lost 10% of my bodyweight. 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