Irritable You can help advance Nephrogenic diabetes insipidus, which can be inherited or acquired, is characterized by an inability to concentrate urine despite normal or elevated plasma concentrations of the antidiuretic hormone arginine vasopressin.
NDI is a distinct disorder caused by complete or partial resistance of the kidneys to arginine vasopressin (AVP). 2012 Dec;27(12):2183-204. doi: 10.1007/s00467-012-2118-8. See our How is it inherited? Nephrogenic diabetes insipidus is not the same as diabetes mellitus. Congenital nephrogenic diabetes insipidus is a disorder associated with mutations in either the AVPR2 or AQP2 gene, causing the inability of patients to concentrate their urine. Last updated: 12/23/2016 What treatments are available? The gene is located in chromosomal region Xq28. 2019 Apr 29;32:210. doi: 10.11604/pamj.2019.32.210.6006. The anti-diuretic hormone arginine-vasopressin (AVP) is released from the pituitary and regulates water reabsorption in the principal cells of the kidney collecting duct. Polyuria, with hyposthenuria, and polydipsia are the cardinal clinical manifestations of the disease. 2009;89:15-29. doi: 10.1016/S1877-1173(09)89002-9. 2006 Nov;2(6):387-404. doi: 10.1016/j.nephro.2006.07.010. A few mutant receptors reach the cell surface but are unable to bind arginine vasopressin or to properly trigger an intracellular cyclic AMP signal. They can direct you to research, resources, and services. He has been taking indomethacin and hydrochlorothiazide and his urine output is fairly well controlled.
Increased urine output Acquired nephrogenic diabetes insipidus can be caused by electrolyte imbalances (e.g., hypercalcemia, hypokalemia), renal/extra-renal diseases and drugs (e.g., lithium toxicity). In nephrogenic diabetes insipidus, the kidneys can't respond to a hormone that regulates fluid balance. Mental deficiency The team may include a How it it diagnosed? Nephrogenic diabetes insipidus is a disorder of water balance. Renal failure in adulthood About 90 percent of all cases of hereditary nephrogenic diabetes insipidus result from mutations in the The acquired form of nephrogenic diabetes insipidus can result from chronic kidney disease, certain medications (such as lithium), low levels of potassium in the blood (hypokalemia), high levels of calcium in the blood (hypercalcemia), or an obstruction of the urinary tract.When nephrogenic diabetes insipidus results from mutations in the When nephrogenic diabetes insipidus is caused by mutations in the Genetics Home Reference has merged with MedlinePlus. The in-depth resources contain medical and scientific language that may be hard to understand. Epub 2009 Oct 7. Nephrogenic diabetes insipidus, which can be inherited or acquired, is characterized by an inability to concentrate urine despite normal or elevated plasma concentrations of the antidiuretic hormone arginine vasopressin. About 90% of patients with congenital nephrogenic diabetes insipidus are males with the X-linked recessive form of the disease (OMIM 304800) who have mutations in the arginine vasopressin receptor 2 gene (AVPR2), which codes for the vasopressin V2 receptor.
In <10% of the families studied, congenital nephrogenic diabetes insipidus has an autosomal-recessive or autosomal-dominant (OMIM 222000 and 125800, respectively) mode of inheritance.