5. This conversion is thought to result from first-pass intestinal and hepatic metabolism through enzymatic hydrolysis. By continuing to browse the site, you are agreeing to our The material on this site is provided for informational purposes only and is not medical advice. If nursing mothers have herpetic lesions near or on the breast, breast-feeding should be avoided.Aciclovir topical cream is commonly associated (≥1% of patients) with: dry or flaking skin or transient stinging/burning sensations. Isolated crystalluria and asymptomatic AKI are most common, but nausea/vomiting and flank/abdominal pain may occur. Maternal Levels.A 4-month-postpartum women was taking 200 mg orally 5 times daily every 4 hours while awake. 1. Epidemiology and prevention of vaccine-preventable diseases.
There was a reduction of incidence of PROM at 36 weeks but this was not statistically significant in the ACV and placebo arms.
If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Acyclovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve). Concomitant administration of cimetidine and probenecid reduces the rate of valaciclovir conversion to aciclovir, but the effect is not clinically significant.Acyclovir is a nucleoside analog that possesses activity against the herpes family of viruses, including herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). The authors estimated that a fully breastfed infant would receive 0.73 mg/kg/day of acyclovir at this maternal dosage or about 1% of the maternal weight-adjusted dosage. [4] A mother nursing her 7-month-old infant took acyclovir 800 mg orally 5 times a day. down the sink or in the toilet) or in household garbage. Many of these side effects can be managed, and some may go away on their own over time. Acyclovir is excreted in human milk. The side effects listed below are not experienced by everyone who takes this medication. What other drugs will affect acyclovir? Acyclovir belongs to the family of medications known as antivirals. If you miss a dose, take it as soon as possible and continue with your regular schedule. It’s also available as a generic drug. [5] A woman who was 6 weeks postpartum received intravenous acyclovir 300 mg (5 mg/kg) 3 times daily for 5 days. Acyclovir will not cure genital herpes and may not stop the spread of genital herpes to other people. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genital herpes simplex and recurrent orofacial herpes simplex. Acyclovir in milk samples taken after the last dose decreased with a half-life of 2.8 hours. Acyclovir is relatively insoluble in the urine, which accounts for its intratubular precipitation at high concentration or with low urine flow rates, resulting in intrarenal urinary obstruction. Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. These include cold sores, genital herpes, chickenpox, and shingles. Additive aciclovir-induced nephrotoxicity in patients receiving concomitant cyclosporine therapy has been suggested. A few reports have linked intravenous acyclovir use with CNS disturbances, including agitation, hallucinations, disorientation, tremors, and myoclonus.Data on outcomes from pregnant mothers exposed to acyclovir during pregnancy showed that the rate of birth defects did not exceed that expected in the general population and the pattern of defects did not differ from those in untreated women.Renal dysfunction (including cases of acute renal failure) resulting from accumulation of aciclovir crystals in the kidneys has been observed following administration of large doses of aciclovir by rapid intravenous infusion, but is uncommon and usually reversible. Acyclovir is an antiviral drug that helps treat chickenpox, genital herpes, and shingles … Zovirax® (acyclovir sodium) for injection prescribing information. Prophylaxis is typically continued for a minimum of 1 year after HCT, and continued for as long as patients continue to require immunosuppressive medications.