Baclofen (Lioresal, Kemstro) is a muscle relaxant drug used for treating muscle spasms, rigidity, and pain from conditions such as multiple sclerosis (MS). Baclofen is excreted primarily by the kidney in unchanged form and there is relatively large intersubject variation in absorption and/or elimination.Baclofen is useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.Patients should have reversible spasticity so that baclofen treatment will aid in restoring residual function.Baclofen may also be of some value in patients with spinal cord injuries and other spinal cord diseases.
"There was also an increased incidence of incomplete sternebral ossification in fetuses of rats given approximately 13 times the maximum recommended human dose, and an increased incidence of unossified phalangeal nuclei of forelimbs and hindlimbs in fetuses of rabbits given approximately 7 times the maximum recommended human dose. In 1 case report, a woman received 80 mg of oral baclofen daily during pregnancy and post-partum. Neonatal Withdrawal Symptoms: Withdrawal symptoms have been reported starting hours to daysafter delivery in neonates whose mothers were treated with oral baclofen throughout pregnancy. Common side effects include sleepiness, weakness, and dizziness.Baclofen was approved for medical use in the United States in 1977.Briefly, adverse effects may include drowsiness, dizziness, weakness, fatigue, headache, trouble sleeping, nausea and vomiting, urinary retention, or constipation. Baclofen is being studied for the treatment of alcoholism.From 2014 to 2017 baclofen misuse, toxicity and use in suicide attempts among adults in the US increased.InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) In studies with animals baclofen has been shown to have general CNS depressant properties as indicated by the production of sedation with tolerance, somnolence, ataxia, and respiratory and cardiovascular depression. Baclofen has a structure and function similar to the neurotransmitter GABA. Foetal/neonatal adverse reactions In order to prevent NAS, the neonate was placed on oral baclofen at initial dosage of 0.1 mg/kg/day for 4 days, followed by a daily decrease of 0.01 mg/kg/day until the drug was discontinued after 13 days. It is slightly soluble in water, very slightly soluble in methanol and insoluble in chloroform.Each tablet, for oral administration, contains 10 mg or 20 mg baclofen. Some like to place Baclofen Pregnancy Category New York Times Bestselling classic poetry book the health of millions cooking process while Baclofen Pregnancy Category who suffer an inordinate in at once and beginning of a journey. Common side effects include sleepiness, weakness, and dizziness. Dispense in a tight light-resistant container as defined by USP. Available in bottles of 100 (NDC 10135-0532-01), 500 (NDC 10135-0532-05) and 1000 (NDC 10135-0532-10).Baclofen Tablets, USP, 20 mg are available as a white round flat-faced beveled edge bisected tablet debossed with “LCI” over “1337” on one side and plain on the other side, containing 20 mg Baclofen USP.
The structural formula is:Baclofen USP is a white to off-white, odorless or practically odorless crystalline powder. Common side effects of baclofen are low blood pressure, vomiting, nausea, headache, and seizures. Baclofen is rapidly and extensively absorbed and eliminated. If benefits are not evident after a reasonable trial period, patients should be slowly withdrawn from the drug (see Baclofen Tablets, USP, 10 mg are available as a white round flat-faced beveled edge bisected tablet debossed with “LCI” over “1330” on one side and plain on the other side, containing 10 mg Baclofen USP. There are no studies in pregnant women. Available in bottles of 100 (NDC 10135-0533-01), 500 (NDC 10135-0533-05), 1000 (NDC 10135-0533-10)PHARMACIST: Dispense in a well-closed container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Store between 20°-25°C (68°-77°F). We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. Pregnancy Category D … In one controlled study of 175 patients, transient drowsiness was observed in 63% of those receiving baclofen compared to 36% of those in the placebo group. Brand names include Beklo, Baclodol, Flexibac, Gablofen, Kemstro, Liofen, Lioresal, Lyflex, Clofen, Muslofen, Bacloren, Baklofen, Sclerofen, Pacifen and others. Could amitriptyline cause other pregnancy …