Like other macrolides, it then penetrates bacteria cell wall and reversibly binds to domain V of the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome, blocking translocation of aminoacyl transfer-RNA and polypeptide synthesis. InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione[H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)OCContact us to learn more about our customized products and solutions.As part of our commitment to providing the most up-to-date drug information, we will be releasing PI Trade Names and Active Ingredients containing fusidate sodium 250 mg tablet, 36. Ezetimibe and simvastatin is not approved for use by anyone younger than 10 years old. This medicine should not be given to a girl who has not yet had menstrual periods.Follow all directions on your prescription label and read all medication guides or instruction sheets.
You should not use this medicine if you are allergic to simvastatin (Do not breastfeed while taking ezetimibe and simvastatin.Other medicines may increase your risk of serious muscle problems if you take them together with ezetimibe and simvastatin. Allergic reactions ranging from urticaria and mild skin eruptions to rare cases of anaphylaxis and Stevens-Johnson syndrome have also occurred. Avoid eating foods high in fat or cholesterol, or ezetimibe and simvastatin will not be as effective.Your pharmacist can provide more information about ezetimibe and simvastatin.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins.". Transient hearing loss with high doses has been observed. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. tors (protease inhibitors, azole antifungals, erythromycin, clarithromycin, telithro-mycin, nefazodone, boceprevir, telaprevir, or grapefruit juice), gemfibrozil, cyclo-sporine or danazol (qrisk of myopathy/rhabdomyolysis); Active liver disease or unexplained persistant elevations in AST/ALT; OB, Lactation: Pregnancyorlacta-tion. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. These medications are not usually taken together. Keep the bottle tightly closed when not in use.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Hepatic - predominantly metabolized by CYP3A4 resulting in numerous drug interactions.After a 250 mg tablet every 12 hours, approximately 20% of the dose is excreted in the urine as clarithromycin, while after a 500 mg tablet every 12 hours, the urinary excretion of clarithromycin is somewhat greater, approximately 30%.Symptoms of toxicity include diarrhea, nausea, abnormal taste, dyspepsia, and abdominal discomfort. Know how this interaction affects the subject drug.A unique ID assigned by the FDA when a product is submitted for approval by the labeller.A governmentally-recognized ID which uniquely identifies the product within its regulatory market.A unique ID assigned by the FDA when a product is submitted for approval by the labeller.A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Jih-Hua Liu, David A. Riley, "Preparation of crystal form II of clarithromycin." Drug information contained herein may be time sensitive. The absence of an interaction does not necessarily mean no interactions exist. This eMedTV article explains what may happen if these drugs are taken together and lists other products that may cause an interaction. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Use the medicine exactly as directed.Take this medicine in the evening, with or without food.Make sure any doctor caring for you knows you that you use ezetimibe and simvastatin, especially if you have an infection, injury or surgery.Ezetimibe and simvastatin is only part of a complete program of treatment that also includes diet, Store at room temperature away from moisture and heat. Hepatic failure is usually reversible, but fatalities have been reported.