By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Clozapine, an atypical antipsychotic agent with few of the extrapyramidal side effects of other antipsychotic agents, was approved for use in the United States in 1989. ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V. This case and others reported in the literature confirm that signs and symptoms after clozapine intoxication are variable and that high plasma levels are not lethal in every case. of our knowledge, the present case is only the second docu-mented report of a patient with FHF leading to death as a result of treatment with clozapine (2). Because of drug-induced agranulocytosis, it is dispensed only under rigid guidelines. Of three reported cases, one death was attributed to a 2 gm ingestion in which the patient went into cardio- pulmonary arrest a few hours after the ingestion. Clozapine-induced eosinophilia had been reported in several studies about blood dyscrasias in clozapine-treated patient. Publication types. The drug is metabolized in the liver via the cytochrome P450 pathway. As with all medicines, it is possible for a person to overdose on clozapine. Clozapine-induced-fever is a common side-effect, with an incidence of 0.5% to 55% (9,10) and there seems to be a close correlation between fever and the first step of clozapine medication. Deaths sec- ondary to clozapine overdose are extremely rare. The mechanism of clozapine-induced liver injury is unclear. The largest study with 2404 patients in Italy found the incidence of 2.2% by criteria of more than 0.4 × 10 9 /l.
Clozapine is an antipsychotic drug indicated for treatment-resistant schizophrenia. Because of drug-induced agranulocytosis, it is dispensed only under rigid guidelines. Clozapine (Clozaril ®, FazaClo ®) is a medication that is used to treat schizophrenia. The clozapine plasma level 24 hours after the first measurement was normal. Overdose has been rare. Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop.We use cookies to help provide and enhance our service and tailor content and ads. It has been suggested that patients who experience Overdose has been rare. ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V. Clozapine, an atypical antipsychotic agent with few of the extrapyramidal side effects of other antipsychotic agents, was approved for use in the United States in 1989. These symptoms and signs disappeared a few days after discontinuation of clozapine. We report the case of a multiple drug interaction involving clozapine, antifungals and oral contraceptives, which resulted in an increased clozapine plasma level, pericarditis with pericardial effusion and eosinophilia in a young Caucasian woman. Clozapine, an atypical antipsychotic agent with few of the extrapyramidal side effects of other antipsychotic agents, was approved for use in the United States in 1989. Because of drug-induced agranulocytosis, it is dispensed only under rigid guidelines. Clozapine blood levels are influenced by age, gender, ethnicity, physical illnesses like liver failure, changes in the activity of the cytochrome oxidase en… Associated cases of pancreatitis, hepatitis, colitis, nephritis, and myocarditis were reported. At autopsy, the reported blood level of clozapine was 5810 ng/mL (6). Clozapine at toxic doses may cause hyperthermia, alterations in consciousness, seizures, cardiac arrhythmias, excessive mucus production in bronchi, hypersalivation, miosis, blood dyscrasias, pancreatitis and hepatitis (Sartorius et al., 2002). Case Reports. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Presented here is a case of clozapine overdose treated successfully with supportive care in which agranulocytosis did not develop.We use cookies to help provide and enhance our service and tailor content and ads. Clozapine is an antipsychotic agent having immuno-modulatory effects. Overdose has been rare.