Flavoxate hydrochloride tablets contain Flavoxate hydrochloride, a synthetic urinary tract spasmolytic.Chemically, Flavoxate hydrochloride is 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4 H-1-benzopyran-8-carboxylate hydrochloride.
Click on a plot to see the median, interquartile range, low and high data points. The molecular weight is 427.94. A value of zero indicates that no data are available. 2015 Jul;26(7):959-66. doi: 10.1007/s00192-014-2585-5.
Brenner GN (2000). The antispasmodic activity of a drug can be correlated with inhibition of cyclic AMP phosphodiesterase, and since papaverine is a potent PDE inhibitor, we tested flavoxate for this activity.
Oxybutynin has a high level of unwanted effects; … For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. 1985 Apr;274(2):189-200.Cazzulani P, Pietra C, Abbiati GA, Ceserani R, Oliva D, Civelli M, Tajana A, Nardi D.Rodríguez-Ramos F, González-Andrade M, Navarrete A.J Pharm Pharmacol. These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. In addition, this agent has been found to inhibit INDICATIONS AND USAGE. In order to study the mode of action of flavoxate, the following activities were investigated: calcium blocking, inhibition of cyclic AMP phosphodiesterase (PDE), local anaesthetic activity, the effects on the synthesis and release of prostaglandins. In a single study of 11 normal male subjects, the time to onset of action was 55 minutes. 2D Structure.
Properties were generated using the CDK toolkit. Previous studies on the mode of action of flavoxate have shown that the drug exerts a selective and direct muscle relaxant activity. For other types of ligands, e.g. The effects of flavoxate hydrochloride (Bladderon®, piperidinoethyl‐3‐methylflavone‐8‐carboxylate; hereafter referred as flavoxate) on voltage‐dependent nifedipine‐sensitive inward Ba 2+ currents in human detrusor myocytes were investigated using a conventional whole‐cell patch‐clamp. Flavoxate binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. Antimuscarinic. Cazzulani P, Panzarasa R, De Stefani C, Graziani G.Arch Int Pharmacodyn Ther. This site needs JavaScript to work properly. Epub 2011 May 19.Acta Pharmacol Toxicol (Copenh). See also.
Flavoxate is contraindicated in patients who have any of the following obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastrointestinal hemorrhage and obstructive uropathies of the lower urinary tract.
1988 Apr;35(4):477-94. doi: 10.2165/00003495-198835040-00006. 2D Structure .
Epub 2014 Dec 6.Tomoda T, Zhu HL, Iwasa K, Aishima M, Shibata A, Seki N, Naito S, Teramoto N.Naunyn Schmiedebergs Arch Pharmacol. Anticholinergic drugs, such as atropine and emepronium, did not exert a similar action. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.Calculated molecular properties are available for small molecules and natural products (not peptides). Therefore, the mode of action of flavoxate can be related to a superimposition of myotropic, calcium antagonistic and local anaesthetic activity. Previous studies on the mode of action of flavoxate have shown that the drug exerts a selective and direct muscle relaxant activity. Both drugs may cause dry mouth and blurred vision, and may precipitate glaucoma. Name must be less than 100 characters For other types … Tension measurement was also performed to study the effects of flavoxate … An image of the ligand's 2D structure. Epub 2007 Oct 2.O'Dwyer PJ, Shoemaker D, Zaharko DS, Grieshaber C, Plowman J, Corbett T, Valeriote F, King SA, Cradock J, Hoth DF, et al.Cancer Chemother Pharmacol. CLINICAL PHARMACOLOGY. Flavoxate Hydrochloride is the hydrochloride salt form of flavoxate, a parasympatholytic agent with antispasmodic activity.Flavoxate hydrochloride competitively binds to muscarinic receptors, thereby preventing the actions of acetylcholine.This relaxes vascular smooth muscle, mainly of the urinary tract, and prevents smooth muscle contractions. … 57% of the flavoxate hydrochloride was excreted in the urine within 24 hours. 2007 Nov;376(3):195-203. doi: 10.1007/s00210-007-0190-6. The empirical formula of Flavoxate hydrochloride is C 24H 25NO 4•HCl.
It also showed the same local anaesthetic activity of lidocaine. In the K+-depolarized guinea-pig taenia coli, contracted by CaCl2, flavoxate and papaverine showed a moderate calcium antagonistic activity.
Finally, the synthesis and release of prostaglandins by urinary bladder muscle in vitro have been investigated before and after treatment with flavoxate. For more info on each category see the Flavoxate hydrochloride counteracts smooth muscle spasm of the urinary tract and exerts its effect directly on the muscle. 2011 Jul;63(7):926-35. doi: 10.1111/j.2042-7158.2011.01275.x. Please enable it to take advantage of the complete set of features! Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor.