Table 1. Patients with drug-induced diabetes insipidus pre-sent with complaints of polyuria, polydipsia or both. Diabetes insipidus starts in childhood or early adult life and is more common in men than women. Drugs may cause hypernatraemia due to free water loss; rarely hypernatraemia may result from the administration of hypertonic sodium solutions (Table 1). unresponsiveness of the kidneys to the action of antidiuretic hormone. 12 hours of water deprivation) or by administration of a modified antidiuretic hormone, desmopressin, to demonstrate the renal unresponsiveness. Which drugs can cause diabetes insipidus (DI)? Please enable it to take advantage of the complete set of features! The cause varies depending on the type of diabetes insipidus you have:The defect may be due to an inherited (genetic) disorder or a chronic kidney disorder. Name must be less than 100 characters Select drug class All drug classes - thiazide diuretics (4) - antidiuretic hormones (7) 7(12):701-14. It also leads you to produce large amounts of urine.While the terms "diabetes insipidus" and "diabetes mellitus" sound similar, they're not related. unresponsiveness of the kidneys to the action of antidiuretic hormone. This website also contains material copyrighted by 3rd parties. After lithium, foscarnet and clozapine were the next most commonly reported causes of drug-induced diabetes insipidus reported to the adverse effect database of the World Health Organization according to a recent search.Click the topic below to receive emails when new articles are available. doi: 10.2165/00002018-199921060-00002. Unable to load your collection due to an error Please see our Comments on Medscape are moderated and should be professional in tone and on topic. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC.
Nephrogenic diabetes insipidus usually affects males, though women can pass the gene on to their children.Diabetes insipidus may lead to dehydration.
Over time, if the medication is taken continuously despite the physical symptoms, it is possible for drug induced diabetes insipidus to turn into nephrogenic or central diabetes insipidus.Lithium is the most common medication that causes diabetes insipidus. Ren Fail. Drug-induced nephrogenic diabetes insipidus caused by other drugs usually occurs in critically ill patients in intensive care units receiving a multitude of drugs dominated by antimicrobials and cytostatics. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). It is important to consider these diseases if a woman presents with diabetes insipidus in pregnancy, because their treatments require … To comment please Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. If you log out, you will be required to enter your username and password the next time you visit. Springer COVID-19 is an emerging, rapidly evolving situation. 2014 Jul 28;5:177. doi: 10.3389/fphar.2014.00177. Drugs Used to Treat Diabetes Insipidus The following list of medications are in some way related to, or used in the treatment of this condition. Nat Rev Endocrinol. These cause DI by impairing hepatic clearance of circulating vasopressinase. Erectile Dysfunction: A Urologic 'Canary in a Coal Mine'MRI Reliably Identifies Significant Prostate Cancer Preserving Ejaculation May Come at a Cost for LUTS Patients Primary polydipsia. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
Updated: Mar 18, 2020 ... Familial forms of diabetes insipidus: clinical and molecular characteristics. Clipboard, Search History, and several other advanced features are temporarily unavailable.
In many instances, ADH suppression is caused by physical changes that have occurred in the central nervous system or the kidneys. Available evidence originates in small studies and case reports. Other treatments include medicines that increase the body to make more ADH. Please see our
2012 May;37(3):E5-6. This is to make up for the amount of … There's no cure for diabetes insipidus. Renal losses (i) Acquired nephrogenic diabetes insipidus Drug … But treatments can relieve your thirst and decrease your urine output.If your condition is serious, urine output can be as much as 20 quarts (about 19 liters) a day if you're drinking a lot of fluids. While the terms "diabetes insipidus" and "diabetes mellitus" sound similar, they're not related. A single copy of these materials may be reprinted for noncommercial personal use only.
Treatment is symptomatic in most patients and the offending drug should be stopped. The condition has also been linked to mental illness, such as schizophrenia.Sometimes, there's no obvious cause of diabetes insipidus.
This causes many people to experience dehydration over time, though dipsogenic diabetes insipidus may actually cause excessive hydration.
This includes NSAIDs such as ibuprofen and water pills (diuretics). Talk with your medical provider about DI and your treatment plan regarding any concerns you may have regarding this condition. Commenting is limited to medical professionals.