The mechanism of its antihypertensive action is due to a direct relaxant effect on vascular smooth muscle thus lowering total peripheral resistance. However, the co-administration of lercanidipine with cyclosporin has caused a 3-fold increase of the plasma levels of lercanidipine and a 21% increase of the cyclosporin AUC. Lercanidipine has been safely administered with diuretics and ACE inhibitors. Accordingly, Lercanidipine HCl should be taken before meals.Distribution from plasma to tissues and organs is rapid and extensive.The degree of serum protein binding of lercanidipine exceeds 98%.
It probably has fewer adverse effects, but a comparatively high potential for drug interactions. This frequency reached 2% in the overall study population including long term clinical trials. Some dihydropyridines may rarely lead to precordial pain or angina pectoris. Since the product has a high protein binding, dialysis is not likely to be effective. Tea of any type is a diuretic, though many are mild diuretics. Lercanidipine HCl is contraindicated in patients with severe hepatic impairment or in patients with severe renal impairment (GFR < 30 ml/min), including patients undergoing dialysis (see sections 4.3 and 4.4)Precautions to be taken before handling or administering the medicinal product:- Treatment should be preferably administered in the morning at least 15 minutes before breakfast.- This product should not been administered with grapefruit juice (see section 4.3 and 4.5). Reversible biochemical changes in the head of spermatozoa which can impair fecundation have been reported in some patients treated by channel blockers. It is unlikely that such changes are of clinical relevance.
This site uses cookies. Lercan 3. Elimination occurs essentially by biotransformationA mean terminal elimination half-life of 8-10 hours was calculated and the therapeutical activity lasts for 24 hours because of its high binding to lipid membrane.
In cases where repeated in-vitro fertilisation is unsuccessful and where another explanation cannot be found, the possibility of calcium channel blockers as the cause should be considered Lercanidipine has minor influence on the ability to drive and use machines. Other medications affecting blood pressure As for all antihypertensive medications, an increased hypotensive effects may be observed when lercanidipine is administered with other medications affecting blood pressure, such as alphablockers for the treatment of urinary symptoms, tricyclic antidepressants, … Oral administration of Lercanidipine HCl leads to plasma levels of lercanidipine not directly proportional to dosage (non-linear kinetics). Date of first authorisation/renewal of the authorisationStart typing to retrieve search suggestions. Side effects include increased urination and sodium loss. Lercanidipine is not recommended during pregnancy and in women of childbearing-potential not using contraception. It is predominantly converted to inactive metabolites and about 50% of the dose is excreted in the urine.Moreover, interaction studies in humans have shown that lercanidipine did not modify the plasma levels of midazolam, a typical substrate of CYP3A4, or of metoprolol, a typical substrate of CYP2D6. Consequently, lercanidipine may be safely administered with β-adrenoceptor blocking drugs, but dose adjustment may be required.Co-administration of 20 mg lercanidipine in patients chronically treated with β-methyldigoxin showed no evidence of pharmacokinetic interaction. Isolated cases of myocardial infarction may be observed.Reporting suspected adverse reactions after authorisation of the medicinal product is important. Lercanidipine should not be used during breastfeeding. ZircolEach of these contain the same drug and work in the same, they are simply produced by different companies.They come in two different doses of 10 mg and 20 mg.
When suggestions are available use up and down arrows to review and ENTER to select. Typical side effects are similar to those of other drugs of this class and include headache, dizziness, Oedemas are significantly less common under lercanidipine when compared to first-generation dihydropyridines such as Overdosing of up to 80 times the usual therapeutic dose has been described. When concomitantly administered at a dose of 20 mg with midazolam p.o.
If you have high blood pressure, taking lercanidipine helps prevent heart disease, heart attacks and strokes.. Lercanidipine is only available on prescription. The drug acts more slowly than older dihydropyridines. *Any unused product or waste material should be disposed of in accordance with local requirements.RECORDATI Industria Chimica e Farmaceutica S.p.A. - Via Matteo Civitali, 1 - 20148 Milan, ITALY.To bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in.