ScienceDirect ® is a registered trademark of Elsevier B.V.The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trialScienceDirect ® is a registered trademark of Elsevier B.V. Nonalcoholic fatty liver disease is a condition where there is an accumulation of fat in the liver even if you do not drink alcohol or drink only a little 2.This type of fatty liver disease is common, and often has no complications or symptoms. NASH, and to a lesser extent NAFLD have been associated with increased liver-related, cardiovascular disease (CVD), and allcause mortality. Monitor your blood sugar closely. Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents. The aim of this clinical trial was to evaluate the effect of melatonin supplement on some important biochemical markers and signs related to NAFLD.A randomized double-blind, placebo-controlled, clinical trial.Twenty-four participants in the melatonin group and 21 participants in the placebo group completed the study.Participants received 6 mg melatonin or placebo daily, 1 h before bedtime. 2009;10(1):5–13. Taking melatonin might decrease the effectiveness of nifedipine GITS for lowering blood pressure.Melatonin might cause sleepiness and drowsiness. Non-alcoholic fatty liver (NAFL) is the initial, reversible stage of liver disease. (check all that apply) There are two types of fatty liver disease, nonalcoholic and alcohol-induced 2. Pediatr Diabetes . Taking melatonin along with fluvoxamine (Luvox) might increase the effects and side effects of melatonin.Melatonin might increase blood sugar. Verapamil (Calan, Covera, Isoptin, Verelan) can increase how quickly the body gets rid of melatonin. 17 Furthermore, few human studies examined the effect of melatonin on leptin and adiponectin serum levels in NAFLD. Good tolerability and safety of melatonin result from its pharmacokinetic properties. Taking melatonin along with sedative medications might cause too much sleepiness.The body makes melatonin. This study is aimed to determine the effects and mechanism of action of melatonin on non-alcoholic fatty liver disease (NAFLD) in … The intervention period was 12 weeks.Anthropometric measurements, systolic and diastolic blood pressure, liver enzymes, high sensitive C‑reactive protein (hs-CRP), fatty liver grade, also leptin and adiponectin serum levels, were measured at the baseline and the end of intervention.A significant improvement was observed in weight (p = 0.043), waist circumference (p = 0.027), abdominal circumference (p = 0.043), systolic (p = 0.039), and diastolic (p = 0.015) blood pressure, leptin serum levels (p = 0.032), hs-CRP (p = 0.024), alanine aminotransferase (p = 0.011), aspartate aminotransferase (p = 0.034), also the grade of fatty liver (p = 0.020) in melatonin treated group compared with the placebo.Administration of 6 mg/day melatonin had improvement effect on many factors related to NAFLD such as liver enzymes, hs-CRP, anthropometric measurements, blood pressure, leptin serum levels and the grade of fatty liver.We use cookies to help provide and enhance our service and tailor content and ads. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Some pilot studies have shown that melatonin, may play a protective role against liver damage through improvement of liver enzymes in nonalcoholic steatohepatitis patients (NASH). Andersen et al. Taking melatonin along with medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system.Melatonin might slow blood clotting.