Mean aortic pressure in this study at 4 hours was lower in the sildenafil than in control animals; the latter group had become became relatively hypertensive by the end of the study. Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model.
Sildenafil, as Revatio 10 mg/ml powder for oral suspension and Revatio 20 mg tablets, is licensed for treating children aged 1 year and over with pulmonary arterial hypertension.These products are not licensed for use in children aged less than 1 year; therefore the use of sildenafil for pulmonary hypertension in neonates is an off‑label use. Within group responses to interventions were evaluated with a repeated measures ANOVA, using Bonferroni's correction for multiple comparisons.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Neither agent had an effect on systemic hemodynamics. A 5F thermodilution catheter (Baxter Healthcare Corp., Irvine, CA) for measurement of pulmonary artery pressure and cardiac output was passed under fluoroscopic guidance through a sheath placed in the left external jugular vein to the origin of the left pulmonary artery. The fall in pulmonary vascular resistance was achieved by a combination of a reduction in pulmonary artery pressure without a change in wedge pressure, and an increase in cardiac output. This situation is called persistent We identified five studies that evaluated effects of sildenafil: three studies that compared sildenafil with We included randomised and quasi-randomised controlled trials of sildenafil compared with We assessed the methodological quality of trials regarding how For this update, we identified two additional studies, for a total of five eligible trials that enrolled 166 infants. Conclusions IV sildenafil was well tolerated, and acute and sustained improvements in oxygenation were noted in those neonates who received the higher infusion doses.
Sildenafil used for treatment of pulmonary hypertension has potential for reducing mortality and improving oxygenation in neonates, especially in resource-limited settings where iNO is not available. Pulmonary vascular resistance fell by 48 ± 8% with intravenous sildenafil, again with a rapid fall between 120 and 180 minutes, and subsequent maintenance of this level (p < 0.05). The cardiac output increased significantly between 120 and 180 minutes, and this increase was subsequently maintained until 240 minutes. Aortic pressure and central venous pressure were unchanged, as was systemic vascular resistance.
One of the major limitations to intravenous vasodilator therapy in patients with pulmonary hypertension has previously been concern regarding the relative lack of selectivity for the pulmonary vasculature. continuous infusion of sildenafil 1.6 mg/kg/day. Inhibition of pulmonary surfactant function by meconium.
Sildenafil for pulmonary hypertension in neonates. Meconium aspiration increased pulmonary vascular resistance by 70%, and increased oxygenation index by over 100%.
This site uses cookies. Persistent pulmonary hypertension secondary to meconium aspiration syndrome is an important cause of morbidity and mortality in the neonatal population. Meconium aspiration syndrome: have we made a difference?