Of 202 evaluable subjects, possible cutaneous sensitization reactions were observed in the same 4 (2%) subjects with both acyclovir cream and placebo, and these reactions to both acyclovir cream and placebo were confirmed in 3 subjects upon rechallenge. Copy the URL below and paste it into your RSS Reader application.
In studies in immunocompromised patients primarily with herpes labialis, there was a decrease in duration of viral shedding and a slight decrease in duration of pain.In studies of recurrent genital herpes and of herpes labialis in nonimmunocompromised patients, there was no evidence of clinical benefit; there was some decrease in duration of viral shedding.ZOVIRAX (acyclovir) Ointment 5% is indicated in the management of initial genital herpes and in limited nonlifethreatening mucocutaneous HSV infections in immunocompromised patients.ZOVIRAX Ointment 5% is contraindicated in patients who develop hypersensitivity to the components of the formulation.ZOVIRAX Ointment 5% is intended for cutaneous use only and should not be used in the eye.In the controlled clinical trials, mild pain (including transient burning and stinging) was reported by about 30% of patients in both the active and placebo arms; treatment was discontinued in 2 of these patients.
Therapy should be initiated as early as possible following the onset of signs or symptoms of herpes labialis, i.e.
Patients should be instructed that Acyclovir Cream is intended for cutaneous use only for herpes labialis of the lips and around the mouth. In this uncontrolled study, acyclovir was detected in the blood of 9 patients and in the urine of all patients tested. Patients should be advised to avoid unnecessary rubbing of the affected area to avoid aggravating or transferring the infection. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. Adult: Moderately emetogenic chemotherapy: 8 mg given 0.5-2 hours prior to chemotherapy, followed by 8 mg after 8 or 12 hours.Highly emetogenic chemotherapy: 24 mg as a single dose, given 0.5-2 hours prior to chemotherapy. and formulary information changes.
In this uncontrolled study, acyclovir was detected in the blood of 9 patients and in the urine of all patients tested.
ZOVIRAX® (acyclovir) Cream, %5. ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpes viruses. Our Zovirax (acyclovir) Cream, 5% Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Patients should be instructed to avoid applying other topical products to the affected area while using Acyclovir Cream.Do not use if you are allergic to Acyclovir Cream or any of the ingredients in Acyclovir Cream. 200 mg every 4 hr. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The dose size per application will vary depending upon the total lesion area but should approximate a one-half inch ribbon of ointment per 4 square inches of surface area. Drugs
Therapy should be initiated as early as possible following the onset of signs or symptoms of herpes labialis i.e., during the prodrome or when lesions appear.For adolescents 12 years of age and older, the dosage is the same as in adults.Each gram of Acyclovir Cream, 5% contains 50 mg of acyclovir.Acyclovir Cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.Acyclovir Cream should only be applied on the affected external aspects of the lips and face in patients with herpes labialis.
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Subsequent doses are administered 4 and 8 hours after the first dose of Ondansetron Injection.
DESCRIPTION. Another study, enrolling 251 healthy adults, was conducted to evaluate the contact sensitization potential of acyclovir cream using repeat insult patch testing methodology. In cell culture, acyclovir triphosphate stops replication of herpes viral DNA.