This review provides an up-to-date overview of cisplatin-associated ototoxicity, namely, its clinical features, incidence rates, and molecular and cellular mechanisms and risk factors, to health care practitioners managing the patient with cancer, and highlights the need for a team-based approach to complement an audiological monitoring programme to mitigate any further loss in the quality of life of affected patients, as there is currently no otoprotective agent recommended routinely for the prevention of cisplatin-associated ototoxicity.
All authors read and approved the final manuscript.The study is supported by the Medical Research Council of South Africa in terms of the National Health Scholarship Programme provided for this purpose by the National Department of Health.
The posterior canal detects rolling motion, or motion about the X axis; the anterior canal detects pitch, or motion about the Y axis; the horizontal canal detects yaw motion, or motion about the Z axis. Cisplatin is an effective drug used in the treatment of many cancers, yet its ototoxic potential places cancer patients, exposed to this drug, at risk of hearing loss, thus negatively impacting further on a patient’s quality of life. It is the snail-shaped shell containing several nerve endings that makes hearing possible.The semi-circular canals are three bony structures filled with fluid. Scientific studies are required to confirm whether a drug is ototoxic. There is currently no cure for permanent ototoxicity; however, hearing aids can improve the effects of hearing loss and help people with ototoxicity live normal lives.
Ototoxicity is the hearing loss caused by drugs or substances that harm the hearing system. The study also received financial support from Oticon Foundation.Copyright © 2016 Jessica Paken et al. Running these searches yielded a total of 2106 records, of which 1581 were excluded based on the title and/or abstract as well as duplication. Over 100 million Americans qualify for low prices on hearing aids through TruHearing. Ototoxicity has been mentioned occasionally over the years; tinnitus and deafness can occur in relation to high doses; symptoms described after injection of chloroquine phosphate include a case of cochlear vestibular dysfunction in a child [32].However, there is insufficient evidence to attribute ototoxicity to chloroquine in humans, except as a rare individualized phenomenon. It also sets the platform for effective dialogue towards policy formulation and strengthening of health systems in developing countries.Cancer places a huge burden on society and has been identified as the leading cause of death in both more and less economically developed countries [The basis for chemotherapy is anticancer drugs containing platinum, that is, cisplatin (cis-diamminedichloroplatinum II) and carboplatin (cis-diammine 1,1-cyclobutane dicarboxylatoplatinum II) [Ototoxicity refers to the hearing disorder that results from the temporary or permanent inner ear dysfunction after treatment with an ototoxic drug [The review identified peer-reviewed articles available from January 1975 to July 2015 on the topic of cisplatin-associated ototoxicity and ototoxicity monitoring and included English articles only.
Serious dose-limiting side effects like ototoxicity, nephrotoxicity and neurotoxicity occur with the use of this agent. It is paramount for health care practitioners managing such patients to be aware of cisplatin’s ototoxic properties and the clinical signs to identify patients at risk of developing hearing loss. Ototoxicity of cisplatin can be reduced by various protective agents. Diagnosis of ototoxicity typically results from ruling out all other possible sources of hearing loss and is often the catchall explanation for the symptoms. When assessing the safety of a drug prior to releasing it on the market, the U.S. Food and Drug Administration (FDA) does not require testing of inner ear function or examination of the inner ear structures.
Frequency lowering is used to overcome the limits of either the bandwidth of the device or the functional bandwidth of the ear, by lowering high frequency energy to a region that is more likely to provide and/or benefit from audible sound [ As with the vestibule, the primary purpose of the canals is to detect movement.
This is an open access article distributed under the We are committed to sharing findings related to COVID-19 as quickly as possible. Seventy-nine articles and two books were identified for this review, using MeSH terms and keywords such as “ototoxicity”, “cisplatin”, “hearing loss”, and “ototoxicity monitoring”.
Physical therapy may prove useful for regaining balance and walking abilities. A 2018 informational bulletin by the US No specific treatment may be available, but withdrawal of the ototoxic drug may be warranted when the consequences of doing so are less severe than those of the ototoxicity.Ototoxic monitoring during exposure is recommended by the American Academy of Audiology to allow for proper detection and possible prevention or rehabilitation of the hearing loss through a It is difficult to distinguish between nerve damage and structural damage due to similarity of the symptoms.
This is one reason it is almost impossible to say with confidence how many and which drugs cause ototoxicity and how many or which people are affected by it.