2020 May 19;12(5):1468. doi: 10.3390/nu12051468.Gut.
The research on the gut microbiome, a primary interest of co-author Gail Cresci, PhD, RD, of the Pediatric Gastroenterology Department and the Lerner Research Institute, reveals that by altering the pH in the gut, PPIs eliminate our first line of defense against ingested pathogens. 2016 May;65(5):740-8. doi: 10.1136/gutjnl-2015-310376. More studies are clearly needed to understand the role of commonly used medication in altering the gut microbiota as well as the subsequent health consequences. 2016 May;65(5):749-56. doi: 10.1136/gutjnl-2015-310861. Proton pump inhibitors (PPIs), used to treat gastro-esophageal reflux and prevent gastric ulcers, are among the most widely used drugs in the world. Unable to load your delegates due to an error PPI users had less diversity in their gut bacteria. In addition to this research, a study published in JAMA Internal Medicine revealed PPI users were more likely to experience recurrent Clostridium difficile infections, leading the researchers to caution against unnecessary PPI usage. While the relationship between PPI use, especially continuous PPI use, and the gastric/gut microbiota is not fully understood, it is also unclear whether long-term PPI use affects the gastric and gut microbiota. Epub 2019 Apr 25.Jackson MA, Goodrich JK, Maxan ME, Freedberg DE, Abrams JA, Poole AC, Sutter JL, Welter D, Ley RE, Bell JT, Spector TD, Steves CJ.Gut. Imhann F, Bonder MJ, Vich Vila A, Fu J, Mujagic Z, Vork L, Tigchelaar EF, Jankipersadsing SA, Cenit MC, Harmsen HJ, Dijkstra G, Franke L, Xavier RJ, Jonkers D, Wijmenga C, Weersma RK, Zhernakova A.Gut.
COVID-19 is an emerging, rapidly evolving situation. Taylor & Francis Epub 2015 Dec 30.Bruno G, Zaccari P, Rocco G, Scalese G, Panetta C, Porowska B, Pontone S, Severi C.World J Gastroenterol. Epub 2020 May 14. PPI impact on the gut microbiome. 2020 Jun 15;17(6):e1003140. PPI users had an increased amount of potentially pathogenic gut bacteria. Since the gut microbiota can, depending on composition, increase or decrease the risk of enteric infections, we investigated the effect of PPI-use on the gut microbiota. Background and aims Proton pump inhibitors (PPIs) are among the top 10 most widely used drugs in the world. Free PMC article We discovered profound differences in the gut microbiota of PPI users: 20% of their bacterial taxa were statistically significantly altered compared with those of non-users. Inter-individual gut microbiota variation (Bray-Curtis… Inter-individual gut microbiota variation (Bray-Curtis distance) explained by commonly used medication at FDR… Gut microbiota changes associated with PPI use that increase the risk of doi: 10.1080/19490976.2017.1284732. Epub 2018 Aug 2.Assumpção PP, Barra WF, Ishak G, Coelho LGV, Coimbra FJF, Freitas HC, Dias-Neto E, Camargo MC, Szklo M.BMC Gastroenterol. Some natural supplements that may be used are Replenish and Multistrain50.
2020 Jun 18;13:2093-2108. doi: 10.2147/DMSO.S237454.
Unable to load your collection due to an error difficile,is the most common cause of infectious diarrhea in the world. Clostridium difficile, orC. Taylor & Francis Figure from Zhernakova et al. Clipboard, Search History, and several other advanced features are temporarily unavailable.
eCollection 2020 Jun.Butler MI, Bastiaanssen TFS, Long-Smith C, Berding K, Morkl S, Cusack AM, Strain C, Busca K, Porteous-Allen P, Claesson MJ, Stanton C, Cryan JF, Allen D, Dinan TG.Nutrients. PPI use has been associated with an increased risk of enteric infections, most notably Clostridium difficile. Moreover, we found that it is not only PPIs, but also antibiotics, antidepressants, statins and other commonly used medication were associated with distinct gut microbiota signatures. Moreover, PPI use has also been linked to increases in expression of bacterial invasion genes, which may also mediate the predisposition to CDI in PPI users (Freedberg et al., 2015). 2020 Aug;69(8):1510-1519. doi: 10.1136/gutjnl-2019-320204. doi: 10.1080/19490976.2017.1284732. The use of PPIs is associated with an increased risk of enteric infections. Production and hosting by Elsevier B.V. on behalf of Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China.ScienceDirect ® is a registered trademark of Elsevier B.V.