Follow your doctor's directions carefully. The etiology of heart failure was ischemic in 55%, and non-ischemic in 45%.
Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease).
Digoxin. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC).Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. Watch for signs and symptoms of overdose while you are taking this medicine. It may be given alone or with other diuretic agents that act more proximally in the renal tubule.Aldosterone antagonist activity: Increased levels of the mineralocorticoid, aldosterone, are present in primary and secondary hyperaldosteronism.
Edematous states in which secondary aldosteronism is usually involved include congestive heart failure, hepatic cirrhosis, and nephrotic syndrome. No teratogenic or other embryotoxic effects were observed in mice, but the 20 mg/kg dose caused an increased rate of resorption and a lower number of live fetuses in rabbits.
Therefore, when Aldactone and acetylsalicylic acid are used concomitantly, Aldactone may need to be titrated to higher maintenance dose and the patient should be observed closely to determine if the desired effect is obtained Based on mechanism of action and findings in animal studies, spironolactone may affect sex differentiation of the male during embryogenesis The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss or other adverse outcomes. There were too few non-whites in RALES to evaluate if the effects differ by race. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products.
It may be necessary to reduce the maintenance and digitalization doses when ALDACTONE is administered, and the patient should be carefully monitored to avoid over- or under-digitalization.
... digoxin oral brand names and other generic formulations include: Cardoxin Oral, Digitek … It may also interfere with some laboratory tests that measure the amount of digoxin in your blood. In the absence of metabolic activation, neither Aldactone nor potassium canrenoate has been shown to be mutagenic in mammalian tests In a three-litter reproduction study in which female rats received dietary doses of 15 and 50 mg Aldactone/kg/day, there were no effects on mating and fertility, but there was a small increase in incidence of stillborn pups at 50 mg/kg/day. Do not stop taking this medicine without first checking with your doctor. No increased tumors were seen at doses of 100 mg/kg/day. In an 18-month study using doses of about 50, 150, and 500 mg/kg/day, there were statistically significant increases in benign adenomas of the thyroid and testes and, in male rats, a dose-related increase in proliferative changes in the liver (including hepatocytomegaly and hyperplastic nodules). © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Some early warning signs of overdose are confusion, loss of appetite, nausea, vomiting, diarrhea, or vision problems. These effects were associated with retarded ovarian follicle development and a reduction in circulating estrogen levels, which would be expected to impair mating, fertility, and fecundity.
ALDACTONE has been shown to increase the half-life of digoxin. 70% were NYHA class III and 29% class IV. Blood or urine tests may be needed to check for unwanted effects. Aldactone has known endocrine effects in animals including progestational and antiandrogenic effects.Spironolactone is not present in breastmilk; however, limited data from a lactating woman at 17 days postpartum reports the presence of the active metabolite, canrenone, in human breast milk in low amounts that are expected to be clinically inconsequential.