Tenofovir (TDF) has stronger antiviral effect than adefovir (ADV) against lamivudine (LAM)-resistant hepatitis B virus (HBV). You may want to have a say in this decision, or you may simply want to follow your doctor's recommendation. Epub 2020 Mar 17.Hayashi S, Higashi-Kuwata N, Das D, Tomaya K, Yamada K, Murakami S, Venzon DJ, Hattori SI, Isogawa M, Sarafianos SG, Mitsuya H, Tanaka Y.Antiviral Res. cross-references to other topics, definitions or medical illustrations) is only available in the online version. This site needs JavaScript to work properly.
Wiley If I have a lot of the hepatitis B virus in my blood and my liver enzymes are high, I may need to take medicines to treat the infection and prevent liver disease.2. To minimize the risk of nephrotoxicity as well as other side effects with any of the oral nucleoside analogs, the dose or dosing interval should be modified in patients with HBV with renal insufficiency. (2003). The aim of this review is to summarize the safety profile of the five approved oral nucleoside analogs used to treat chronic hepatitis B virus (HBV) infection, focusing on both the class adverse effects and those that have been reported with individual agents, as well as their safety in pregnancy. Experts recommend antiviral medicines if you have high levels of both the hepatitis B virus and liver enzymes in your blood for at least 6 months or if you have liver disease.It may help to go back and read "Get the Facts." Hepatology, 49(1): 72-79.Hann H-W, et al. (B) When the intracellular concentration of a nucleoside analog exceeds a critical threshold, human mtDNA polymerase gamma activity can be inhibited. Antiviral medicines can stop or slow the growth of the hepatitis B virus and help prevent serious liver problems. 2014 Mar;29(3):428-34. doi: 10.1111/jgh.12499.Pharmacotherapy.
You can use it to talk with your doctor or loved ones about your decision.American Public Health Association (2015). Unable to load your collection due to an error
Washington, DC: American Public Health Association. 2020 Apr;176:104744. doi: 10.1016/j.antiviral.2020.104744.
Either way, this information will help you understand what your choices are so that you can talk to your doctor about them.Here's a record of your answers. Now that you've thought about the facts and your feelings, you may have a general idea of where you stand on this decision. Adefovir and tenofovir are associated with a dose-dependent but usually reversible proximal renal tubular toxicity. This site needs JavaScript to work properly. My doctor says I have a good chance of doing well on interferon. You'll need to have regular exams and blood tests to see if the virus is still active in your body and to find out how well your liver is working.Are you clear about which benefits and side effects matter most to you?Do you have enough support and advice from others to make a choice?How sure do you feel right now about your decision?Check what you need to do before you make this decision.That's right. They are sorted into two groups:Experts recommend antiviral medicines if you have high levels of both the hepatitis B virus and liver But antiviral medicines may not be right for everyone. (2005). Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir. Some people stop taking their medicines because they feel too sick to finish them.That's right. If this happens, you may have to try another medicine. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial. All nucleoside analogs have a "Black Box" warning because of their potential for inhibition of human DNA polymerase gamma involved in mitochondrial DNA replication. The virus can damage liver cells and cause your liver to become swollen and tender. Please enable it to take advantage of the complete set of features! Select drug class All drug classes - nucleoside reverse transcriptase inhibitors (NRTIs) (11) - antineoplastic interferons (4) - antiviral interferons (4) And some can make you feel sick while you are taking them. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B.
Studies show that lamivudine and adefovir can reduce liver damage in about half of the people who take these medicines.Antiviral medicines can have serious side effects that may cause problems throughout your treatment. Collection of a baseline DNA sample and other biological samples during treatment is advisable. 2009 Jun;15(2):179-92. doi: 10.3350/kjhep.2009.15.2.179.Hepatology.