Your email address is used The risk of cataract was reduced by 50 percent when treatment was initiated in younger individuals (in their 40s) and the duration of therapy was longer (e.g. Truth: Some studies have indicated that there may be a relationship between statin drugs and an increased risk for developing cataracts.However, these investigations have been either conducted in animals or in less-than-rigorous studies. However, analysis of the case–control studies and RCTs revealed no association between statin use and the risk of cataract.
Moreover, patients should be stratified according to baseline confounders. Nearly 22 million Americans aged 40 and over have cataracts, while more than one-half of individuals aged 80 and over suffer from this condition.
We also performed subgroup analyses based on study design (case–control, cohort, or RCT), type of statin, the methodological quality of the study (high or low), study location (Europe, North America, Asia or Australia), age, sex, follow‐up duration, outcome and outcome assessment, and whether potential confounders were included in the adjusting model (eg, low‐density lipoprotein included/missing, cardiovascular disease [CVD] included/missing, smoking included/missing).STATA 12.0 software (StataCorp LP, College Station, TX) was used for statistical analysis. Because of the considerable benefits of statins in cardiovascular patients, this issue should not deter the use of statins.
Hippisley-Cox J, 2. In total, 489 articles were excluded after reading the title and abstract, and the full texts of the remaining 120 articles were evaluated in detail. 1.
[OpenUrl][1][Abstract/FREE Full Text][2] Cardiovascular disease is the leading cause of premature death and a major cause of disability in most industrialised nations. 1 Nearly 13 million people in the United States are reported to suffer from cataracts. The primary end points should include not only cardiovascular diseases but also total comorbidity. Phys.org internet news portal provides the latest news on scienceTech Xplore covers the latest engineering, electronics and technology advances Science X Network offers the most comprehensive sci-tech news coverage on the web In the subgroup analysis of cohort studies, the ITwo of the included studies reported that statin use was protective against cataracts.The analysis of the RCTs indicated that statin use does not increase the risk of cataract. Finally, investigators should attempt to characterize and follow the outcomes of those patients who drop out of the trials.Based on the present meta‐analysis of these studies, we could only conclude that there is no clear evidence showing that statin use increases the risk of cataract. Because of the rigorous criteria of RCTs, individuals at greatest risk for adverse events may be excluded. Note: This document contains side effect information about atorvastatin.
Feel free to continue browsing. One of these articles included 2 studies.The main characteristics of the cohort and case–control studies are shown in Tables CPT indicates current procedural terminology; ICD, International Classification of Diseases.CPT indicates current procedural terminology; ICD, International Classification of Diseases; OMXIS, Oxford Medical Information System.RCTs indicates randomized controlled trials; NA indicates not available; OXGRADE, Oxford grading system.The pooled RR of the cohort studies was 1.13 (95% CI, 1.01–1.25), which indicated that the use of statins was associated with a 13% increase in cataract incidence or cataract surgery (Figure The results of the subgroup analyses of the cohort and case–control studies are presented in Tables The results of the subgroup analysis of RCTs are presented in Table When the studies were grouped according to patient age, no association was observed in the older than 60 years subgroup (RR, 0.82; 95% CI, 0.53–1.26) and the no older than 60 years subgroup (RR, 0.97; 95% CI, 0.84–1.11) (Figure When we grouped the studies by follow‐up duration, no significant association was observed in the no more than 5 years group (RR, 0.86; 95% CI, 0.48–1.51) and in the more than 5 years group (RR, 0.95; 95% CI, 0.83–1.08) (Figure In this comprehensive meta‐analysis of 6 cohort, 6 case–control studies, and 5 RCTs, we analyzed the effect of statin use on the risk of cataracts in more than 313 200 patients. 2 Statins are widely prescribed to treat hyperlipidemia, as they reduce the risk of cardiovascular disease by inhibiting 3‐hydroxy‐3‐methyl‐glutaryl‐CoA reductase.