2002 107 108 109 110 127 128 Contact the applicable plan
In severely uremic patients a single dose may produce high blood levels for several days and the cumulative effect may produce ototoxic sequelae. A report of “Intermediate” indicates that the result be considered equivocal, and, if the organism is not fully susceptible to alternative clinically feasible drugs, the test should be repeated. mass its main metabolites in blood and urine. Other moderate to severe infections as 2Renal impairment: reduce dose, monitor renal function and peak serum levels (max 20–25micrograms/mL) periodically.
Two to three months after stopping the drug, gross vestibular symptoms usually disappear, except from the relative inability to walk in total darkness or on very rough terrain.Although streptomycin is the least nephrotoxic of the aminoglycosides, nephrotoxicity does occur rarely.Clinical judgment as to termination of therapy must be exercised when side effects occur.The deltoid area should be used only if well developed such as in certain adults and older children, and then only with caution to avoid radial nerve injury. The total period of drug treatment of tuberculosis is a minimum of 1 year; however, indications for terminating therapy with streptomycin may occur at any time as noted above.2.
and formulary information changes. Dissolve powder with 4.2, 3.2, or 1.8 mL of SWI to prepare 200 mg/mL, 250 mg/mL, or 400 mg/mL. As with all intramuscular injections, aspiration is necessary to help avoid inadvertent injection into a blood vessel.Injection sites should be alternated. Max 120g over entire course of therapy.
A minimum of 10 days of therapy is recommended.5. 2010 Significant amounts have been found in pleural fluid and tuberculous cavities. Any reduction of glomerular function results in decreased excretion of the drug and concurrent rise in serum and tissue levelsStreptomycin sulfate is a bactericidal antibiotic. Following intramuscular injection of 1 g of streptomycin as the sulfate, a peak serum level of 25 to 50 ug/mL is reached within 1 hour, diminishing slowly to about 50 percent after 5 to 6 hours. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Significant amounts have been found in pleural fluid and tuberculous cavities. When streptomycin is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by Two to three minutes should be allowed for complete solution.
Elderly. Streptomycin sulfate 1g/vial; lyophilized pwd for IM inj after reconstitution.Moderate to severe susceptible infections, including plague, tularemia, endocarditis. Because streptomycin readily crosses the placental barrier, caution in use of the drug is important to prevent ototoxicity in the fetus. CLSI Document M100-S21 Vol. Alternate injection sites. injection to be effective in bacterial neonatal sep- sis; bacterial septicemia and seriouson a dilution method (broth or agar) or equivalent bacterial infections of the central nervous system (menin- gitis), urinary tract, respiratory tract, gastrointesti- nal tract (including peritonitis), skin, bone and soft tissue (including burns). Alternate injection sites. As higher doses or more prolonged therapy with streptomycin may be indicated for more severe or fulminating infections (endocarditis, meningitis, etc. Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate] [Usual dose] [100 ml] [30-60 min] (Not approved for IV use, however, has been used in patients with insufficient muscle mass.) Second-line therapy for gram-negative bacillary bacteremia, meningitis, pneumonia, brucellosis, granuloma inguinale, chancroid, UTIs.Give by IM inj into gluteus maximus or mid-lateral thigh. In patients older than 60 years of age the drug should be used at a reduced dosage due to the risk of increased toxicity. Venereal infections: if concomitant syphilis suspected, perform dark field examination before starting therapy then monthly serologic tests for at least 4 months. THESE INCLUDE DISTURBANCES OF VESTIBULAR AND COCHLEAR FUNCTION, OPTIC NERVE DYSFUNCTION, PERIPHERAL NEURITIS, ARACHNOIDITIS, AND ENCEPHALOPATHY MAY ALSO OCCUR.
Applied to atransition … (Not approved for IV use, however, has been used in patients with insufficient muscle mass.)