This can lead to gynecomastia and other negative effects, which tamoxifen can help block.I'm a man who has been on tamoxifen for four months now for breast cancer. Long‐term studies that rigorously document the side‐effect profile of tamoxifen in men are lacking.Estradiol (E2) in males is produced from testosterone by aromatization, and is involved in various biological functions (Wibowo Tamoxifen is indicated as adjuvant therapy for women with ER‐positive early breast cancer (Early Breast Cancer Trialists’ Collaborative Group, To date, tamoxifen has been used as an off‐label treatment in men for breast cancer, infertility, idiopathic gynecomastia, and more recently, for iatrogenic gynecomastia because of the use of non‐steroidal antiandrogens in the treatment of prostate cancer patients (Hedlund, Here, we review the studies to summarize and evaluate the AE profile of tamoxifen in different male populations, specifically men with prostate cancer, breast cancer, infertility, and idiopathic gynecomastia.
We thank Joanne Phillips for proof‐reading the tables.EW and NH performed the literature search.
Also, the frequency at which AEs occur varies – less AEs in men with infertility and idiopathic gynecomastia compared to men with prostate cancer or breast cancer. I was on tamoxifen for a short time (for bodybuilding reasons) and I only experienced decrease in libido, nothing else. Tamoxifen, an estrogen antagonist, is effective for recent-onset and tender gynecomastia when used in doses of 10-20 mg twice daily.
For men with idiopathic gynecomastia that causes discomfort and lasts more than three months, a short course (three to six months) of tamoxifen or raloxifene may be recommended.
As a result of this effort I have lost 18 pounds, but I have to work very hard for every pound.
While this type of cancer is fairly rare in men, the type that most men get involves Doctors also use tamoxifen for men who suffer from gynecomastia, where the breasts become enlarged and often sore or tender.
He thinks it's causing hair loss as well. Bodybuilders and other athletes who take steroids to improve performance suppress their production of the hormone androgen, and their bodies may compensate by overproducing estrogen. My dad is on tamoxifen. However, if this sex difference is real, one possible factor is a difference in activity of cytochrome P450 enzymes that metabolize tamoxifen in the liver (Anderson, Before starting any treatment, patients should be informed of the AEs they are most likely to experience (Hofman Of the deaths that were reported in men while receiving tamoxifen (all were cancer patients), most were attributed to disease progression. Tamoxifen is also known to help men who take anabolic steroid cycles to increase muscle mass avoid gynecomastia from the hormonal changes caused by the steroids. In the first step, we reviewed the abstracts from the original search results, and we excluded studies if they presented data on: (i) women; (ii) unrelated medical conditions; (iii) other SERMs (e.g., toremifene, raloxifene). I experienced it after steroid use.
Prior to analysis, the studies were divided into the following patient populations: (i) prostate cancer receiving antiandrogens, (ii) prostate cancer Based on the Cochrane Handbook for Systematic Reviews of Interventions (Loke Figure S1 shows our process of identifying RCTs of male patients on tamoxifen.