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Our website services, content, and products are for informational purposes only. Epub 2014 Mar 17.Drug Des Devel Ther. Article Information
Statin Therapy in the Frail Elderly: A Nuanced Decision. RC, CB, CR, JE, LB, AK, JS, and EB collected the data. All collaborators had an opportunity to contribute to the interpretation of the results and to drafting of the report. This collaboration was jointly coordinated by the National Health and Medical Research Council Clinical Trials Centre (CTC) in Australia, and by the Medical Research Council Population Health Research Unit and Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU) in the UK. Clipboard, Search History, and several other advanced features are temporarily unavailable. Statins, the most widely used drugs in the Western world, have become a pivotal component in the primary and secondary prevention of vascular diseases. AS, Fortmann
A new study has shed light on the benefits and risks of people over 75 taking this medication. The present review discusses benefits of intensive vs moderate statin therapy, justifications for the use of aggressive lipid management in the very old and the use of statins in frail elderlies. However, they suggest statins should be considered in older adults with all four of the major risk factors. Epub 2019 Oct 30.Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group.CNS Drugs. Most elderly 85 year olds are frail (even if they have a short PMH) and I think the PATH clinic guidelines are more reasonable. CVD prevention is of increasing importance in people aged 80 years and over. Epub 2016 Nov 12.Ray KK, Kastelein JJ, Boekholdt SM, Nicholls SJ, Khaw KT, Ballantyne CM, Catapano AL, Reiner Ž, Lüscher TF.Eur Heart J. Epub 2011 Jun 13.Li YH, Ueng KC, Jeng JS, Charng MJ, Lin TH, Chien KL, Wang CY, Chao TH, Liu PY, Su CH, Chien SC, Liou CW, Tang SC, Lee CC, Yu TY, Chen JW, Wu CC, Yeh HI; Writing Group of 2017 Taiwan Lipid Guidelines for High Risk Patients.J Formos Med Assoc. D, Williamson
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Although the new study provides support for the use of statins in older adults, it isn’t the final answer.“While many are using this article to claim that statins in people over 75 are completely beneficial, more studies are needed before a conclusion can be made,” Amato said.But for some people, after consulting with their doctor, taking statins may be the right choice for them. “These side effects could lead to falls, injuries, and hospitalizations.”She says right now there’s no clear-cut answer for at what age the risks of statins outweigh the benefits.Although only a handful of studies have looked at the benefits of statins for older adults, Mintz says current guidelines for cholesterol management don’t say people should stop taking a statin just because they turn 75.The 2018 American College of Cardiology and American Heart Association Among older adults without cardiovascular disease, those with LDL (bad) cholesterol of 70 to 189 mg/dL may benefit from starting a moderate-intensity statin, according to the guidelines. However, the absolute effect of a 38.7mg/dl cholesterol lowering on the rate of annual ischemic heart disease mortality is 10-fold larger in older vs younger patients. COVID-19 is an emerging, rapidly evolving situation. Statins are drugs that lower your cholesterol. “And there’s an association for increased cognitive dysfunction in older people who take statins,” Amato said.
Links to the science. They also stabilize cholesterol plaque and reduce inflammation.”“While the data looks like it would suggest that physicians recommend that older people remain on statin medication, we should wait before making that a conclusive recommendation,” Amato said.The results of previous randomized clinical trials is also mixed. The Medical Expenditure Panel Survey reported that statin use for primary prevention in adults older than 79 years increased more than 3-fold, from 8.8% in 1999-2000 to 34.1% in 2011-2012.Is there any justification for such widespread use, or is this an instance of overuse unsupported by evidence?