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After menopause, estrogen is mainly produced by converting androgens (sex hormones produced by the adrenal glands) into estrogens, which occurs in fat cells (as opposed to in the ovaries before menopause). Discover information about different types of cancerLearn about cancer, diagnosis, treatment, coping & survivorshipFind resources & tools for oncology healthcare professionalsAromatase inhibitors (AIs) are a common therapy for post-menopausal women with hormone positive breast cancer. Aromasin Joint Pain Relief The Highest Pharmaceutical Standards.
While the results of this study seem promising, more research is needed to better understand the benefits and risks of high doses of vitamin D, especially over longer periods of time. Breastcancer.org’s EIN is 23-3082851. If these side effects are a problem, talk to your doctor about how to manage them. Five types of interventions were identified that have been studied: pharmacological (drug) approaches, acupuncture, nutritional supplementation, relaxation techniques and physical exercise. Carpal tunnel syndrome is a common diagnosis in women with AI-related joint symptoms. Found at: http://annonc.oxfordjournals.org/content/early/2013/03/06/annonc.mdt037.full.htmlReceive the latest resources and updates in your inbox. Unfortunately, nearly half of women taking AIs report joint pain, or arthralgia. Cerner Multum, Inc. "UK Summary of Product Characteristics." Unfortunately, studies have not found consistent predictors.
Women should be advised about this side effect when starting an AI, and encouraged to report these symptoms to the healthcare team. The oncology team is there to support each patient to complete their prescribed therapy and will help identify ways to manage this side effect. Other diagnoses include osteoarthritis, tendonitis and bursitis.The actual cause of AI-related joint symptoms is not well understood. Re: Aromasin and Joint Pain I have been on aromasin since 11/03. 3. However, these medications are not without side effects of their own, so each patient should discuss his/her health history with the team before starting these medications. But after 4 and 6 months, when the women got high doses of vitamin D monthly instead of weekly, the improvements in pain and movement they had at 2 months went away.Women who got high doses of vitamin D tended to maintain bone health (as measured by the bone mineral density test) better than women who got the placebo.Two women developed high calcium levels in their urine and stopped taking the high doses of vitamin D; other than that, the high doses of vitamin D didn't cause any side effects.The researchers aren't sure how high doses of vitamin D each week helps ease muscle and joint pain that can be caused by Arimidex.High doses of vitamin D can be safe as long as you are closely monitored by a doctor. For some women this pain can be severe. Pharmacological approaches, including duloxetine (Cymbalta), immunotherapy and changing between AI options showed promise in relieving arthralgia symptoms. 2013. I originally had a few weeks of joint pain and then it passed. Doctors aren't sure why aromatase inhibitors cause muscle and joint pain. There may also be an increased risk for those with pre-existing joint symptoms, such as rheumatoid arthritis. Researchers continue to seek ways to identify women at highest risk for developing this side effect and to find effective therapies to treat it. Aromasin is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox) for 2 to 3 years. The following 6 months, I took Aromasin, which has given me slightly less joint pain, with similar symptoms – terrible pain from my fingertips through my wrists and above. Annals of Oncology. It is estimated that 20-30% of patients discontinue AI treatment due to joint pain.