low blood sugar. Carbamazepine is a potent CYP3A4 inducer and repaglinide is a CYP3A4 substrate. It lowers blood sugar and may interfere with your diabetes treatment.pale or yellowed skin, dark colored urine, fever, confusion or weakness; orThis is not a complete list of side effects and others may occur. PRANDIN ® (repaglinide) Tablets (0.5, 1, and 2 mg) Rx only .

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Diabetic ketoacidosis. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvcHJhbmRpbi1yZXBhZ2xpbmlkZS0zNDI3MTg= Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitusMay be dosed 2, 3, or 4 times a day in response to changes in meal patternSerious CV events (4%; versus 3% incidence with glyburide and glipizide)Coadministration of gemfibrozil results in increased repaglinide plasma concentration (8-fold increase); may lead to severe hypoglycemiaStress due to infection, fever, trauma, or surgery; may need to discontinue if exposed to stressPatients at risk of severe hypoglycemia: Elderly, debilitated, or malnourished; adrenal or pituitary insufficiencyMyocardial ischemia reported in patients treated concomitantly with NPH-insulin; not indicated for use in combination with NPH-insulinThe use of sulfonylureas may be associated with increased cardiovascular eventsDrugs that inhibit organic anion transporting protein OATP1B1 (eg, cyclosporine) may increase plasma concentrations of repaglinide, which is a substrate for active hepatic uptake transporter OATP1B1Limited available data from case reports and case series have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal, or fetal outcomes in women taking repaglinide while pregnantDetected in breast milk of rat dams and lowered blood glucose levels were observed in the pupsCross fostering studies indicated that skeletal changes could be induced in control pups nursed by treated dams, although this occurred to a lesser degree than those pups treated in uteroA: Generally acceptable. a condition where the adrenal glands produce less hormones called Addison's disease. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).Avoid drinking alcohol.
Follow all directions on your prescription label and read all medication guides or instruction sheets. You should not use Prandin if you have type 1 diabetes, severe liver disease, or diabetic ketoacidosis. Reduce the dose of PRANDIN if hypoglycemia occurs. severe renal impairment.

This includes prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Prandin only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Version: 9.02.Find out everything you need to know about weight loss drugs in our prescription The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. What you should do about this interaction: Make sure your healthcare professionals (e.g.
Call your doctor for medical advice about side effects. If you log out, you will be required to enter your username and password the next time you visit. Prandin is used together with diet and exercise to improve blood sugar control in adults with You should not use Prandin if you have type 1 diabetes, severe Prandin is only part of a complete program of treatment that also includes diet, exercise, and weight control. DESCRIPTION . Your doctor may occasionally change your dose.Prandin is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Diseases & Conditions The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic drugs, a main side effect concern is hypoglycemia. Your doctor may change your treatment plan if you also use:To make sure Prandin is safe for you, tell your doctor if you have ever had:Follow your doctor's instructions about using Prandin Prandin is not approved for use by anyone younger than 18 years old.Take Prandin exactly as prescribed by your doctor. Carbamazepine: (Major) Coadministration of carbamazepine and repaglinide may decrease the serum concentration of repaglinide; if coadministration is necessary, a dose increase of repaglinide may be required and an increased frequency of glucose monitoring is recommended. Skip the scheduled dose of PRANDIN if a meal is skipped to reduce the risk of hypoglycemia. Alcohol may affect blood glucose levels in patients with diabetes.