When used together, azelastine hydrochloride and fluticasone propionate provide better relief of symptoms than either medicine alone. Fluticasone is a steroid (cortisone-like medicine). It is available as the brand-name drug Astepro.It has structural and chemical differences that distinguish it from currently available antihistamines.It contains fluticasone propionate, a medium-potency man-made corticosteroid (specifical glucocorticoids) that has a very high affinity for the corticosteroid receptors.Avoid alcoholic beverages while taking these medicines since you are amplifying your risk of damaging the liver and kidneys, and it can lead to high blood pressure, dehydration, depression, allergic reactions, chest pain, and gastrointestinal problems.It is not known whether azelastine passes into breast milk or if it could affect in a negative way a nursing baby.Therefore, tell your healthcare provider if you are breastfeeding an infant before using the antihistamine.It is not known whether fluticasone is excreted in human breast milk and if it can affect the breastfed baby.Let your healthcare provider decide whether you should discontinue using the nasal corticosteroid if you are breastfeeding an infant.It is not known whether azelastine will harm an unborn baby.Hence, before using the nasal spray, tell your healthcare provider if you are pregnant.There are no well-adequate studies regarding the safe use of fluticasone propionate in pregnant women.Talk to your healthcare professional before using the nasal corticosteroid.Throw away this antihistamine after you have used 200 sprays, even if there is still medicine left in the bottle.If the spray gets in your mouth or eyes or on your skin, rinse with cool water.Azelastine may interact in a negative way with the following drugs:Flonase may interact in a negative way with the following drugs:For Azelastine, 1 spray per nostril two times per day is the most often recommended dose.Azelastine works by inhibiting the release of histamine from the cells in the body.In addition to acting as a histamine antagonist, this medicine also inhibits the production of free radicals, leukotrienes, and cytokines.After intranasal administration, its systemic bioavailability is around 40 percent.Fluticasone propionate works by reducing the human body’s response to specific allergens.These nasal sprays are indicated for the treatment of both nonallergic vasomotor rhinitis and seasonal allergic rhinitis.Azelastine (brand-name drug – Astepro) is a nonsteroidal anti-inflammatory respiratory investigational medication that has demonstrated activity and safety in the treatment of seasonal allergic rhinitis.It works by preventing histamine (a neurotransmitter) release and by blocking histamine at receptors.According to a 2006 study, azelastine has a comparable action as intranasal fluticasone propionate.Moreover, there is a combination product containing fluticasone propionate and azelastine which has been approved by the US Food and Drug Administration for use in children older than 12 years.As per a 2010 study that was done at the Central Texas Health Research, Texas, US, the combination azelastine-fluticasone nasal spray provided a substantial improvement in the total nasal symptom score compared with either agent alone in sufferers with moderate-to-severe SAR.This combination has the advantage of delivering both a nasal steroid and an antihistamine in one product.Health Guide Net provides qualitative and informative articles on health, diet, and beauty.About 23 million Americans are diagnosed with diabetes. Long term untreated allergic rhinitis may lead on to asthma. It works by preventing the inflammation that occurs with allergic reactions. BACKGROUND: The novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in a single spray (MP-AzeFlu) was compared with a first-line intranasal antihistamine spray (AZE) in Russian seasonal allergic rhinitis (SAR) patients. Azelastine hydrochloride and fluticasone propionate nasal spray, 137 mcg / 50 mcg contains 0.1% solution of azelastine hydrochloride and 0.037% suspension of micronized fluticasone propionate in an isotonic aqueous suspension containing benzalkonium chloride (0.1 mg/g), edetate disodium dihydrate, glycerin, microcrystalline cellulose and carboxymethylcellulose sodium, …
Long term untreated allergic rhinitis may lead on to asthma. 2015 Jul-Aug;29(4):273-82. doi: 10.2500/ajra.2015.29.4215. Name must be less than 100 characters