Dehydration plays an important role in ACV-induced AKI (Vachvanichsanong et al., 1995;Varicella zoster virus is less susceptible than HSV to acyclovir. There was an increase in AKI signal in cases with concomitant use of VACV and NSAIDs, while no increase was detected in cases with concomitant use of VACV and acetaminophen.
Acute VZV infection can lead to isolated, clinically significant kidney failure. Case presentation:
University of Veterinary and Animal Sciences, Pakistan That is, the reported year did not necessarily correspond to the year in which ADE developed. From 30 to 90 days after transplantation when no antiviral medicine was given, 60% (3/5) of the remaining placebo recipients and 44% (7/16) of the acyclovir patients developed active HSV infections. Peritoneal dialysis is less effectiveOur patient presented with severe acute renal failure andneeded repetitive hemodialysis. Acyclovir is an antiviral agent widely used in herpetic infections in children. J Emerg Med 2019; 57:e35. In this report, we present a 16-year-old girl who developed acute renal failure due to acyclovirtreatment and who needed repetitive hemodialysis. Excessive serum concentrations of acyclovir and neurotoxicity. J InfectRapidly progressive acute renal failure due to acyclovir: casereport and review of the literature. Critical Care Medicine 2010; 38:261-275. renal dose dopamine (<5 g/kg of body weight/min) increases RBF and, to a lesser extent, GFR. However, some NSAIDs have been shown to be associated with increased risk of VACV-related AKI in the FDA spontaneous reporting system (JADER is a Japanese database of adverse event reports submitted to the Pharmaceuticals and Medical Devices Agency (PMDA) and can be accessed from the PMDA website (Adverse events and comorbidities were coded using the preferred terms (PTs) in the Medical Dictionary for Regulatory Activities (MedDRA). Ten months after chemotherapy for lung adenocarcinoma, a 48-year-old woman developed herpes simplex and Candida esophagitis (diagnosis based on cytological findings of a biopsy specimen from endoscopy). Ann Intern Med. Renal biopsy was performed in order to confirm the diagnosis.
One patient was rechallenged with low-dose intravenous acyclovir and the four patients later received oral acyclovir, all without adverse effect. Acyclovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve). In all cases, BX795 demonstrated low toxicity at therapeutic concentration and showed strong antiviral benefits. But in some cases, reduced efficacy has been observed due to the emergence of resistance against these drugs. This site uses cookies. The signals of VACV-related AKI were compared using the ROR. You may report side effects to FDA at 1-800-FDA-1088.Acyclovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, Other drugs may interact with acyclovir, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use acyclovir only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2020 Cerner Multum, Inc. Although acyclovir is gen-erally well tolerated, severe nephrotoxicity has beenreported in some cases. This review provides an overview of drug-induced injuries to the kidney, details on relevant and translational biomarkers, and advances in 3D cultures of human renal cells, including organoids and kidney-on-a-chip platforms.In the past 5 years, microneedles have greatly revolutionized the way drugs can be delivered. Laboratory data showed a serum creatinine level of 2.1 mg/dL; serum potassium 2.1 mmol/L. All rights reserved.]. 1988;108:312.Bayer AS, Friedman GS, et al.