Your Mendeley pairing has expired. Dimenhydrinate (DIM) is an important drug used for the prevention of motion sickness. The crystal structure of DIM contains the anionic form of 8-chlorotheophylline whose existence was confirmed using density functional theory calculation. Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting In this study, we have attempted to determine the structure of DIM through single crystal X-ray structure analysis and confirmed the salt–cocrystal ambiguity. Simultaneous Improvement of Epalrestat Photostability and Solubility via Cocrystallization: A Case Study. Predicting the Crystal Structure of Decitabine by Powder NMR Crystallography: Influence of Long-Range Molecular Packing Symmetry on NMR Parameters. Okky Dwichandra Putra, Daiki Umeda, Eriko Fujita, Tamami Haraguchi, Takahiro Uchida, Etsuo Yonemochi, Hidehiro Uekusa. For permission to reproduce, republish and Information about how to use the RightsLink permission system can be found at Simone Bordignon, Paolo Cerreia Vioglio, Emanuele Priola, Dario Voinovich, Roberto Gobetto, Yusuke Nishiyama, and Michele R. Chierotti . Surprisingly, the crystal structure of DIM has not been determined over the last 67 years.
21 publications.
Reversible on/off switching of photochromic properties in Synthesis, characterization and crystal structure of a new organic salt of antidiabetic drug metformin resulting from a proton transfer reaction. Regulatory Aspects for Formulation Design – with Focus on the Solid State.
Lab Test Considerations: Will cause false-negative allergy skin test results; Okky Dwichandra Putra, Anna Pettersen, Etsuo Yonemochi, Hidehiro Uekusa. Crystal structure of dimenhydrinate (DIM) has been detd. Dimenhydrinate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. system. through single crystal X-ray structure anal. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Kinetic and intrinsic solubility tests were also performed to evaluate the physicochemical properties of DIM raw material.The Supporting Information is available free of charge on the Electronic Supporting Information files are available without a subscription to ACS Web Editions. The 6.25-mg, 12.5-mg, and 25-mg tablets are TILTAB tablets. Acta Crystallographica Section B Structural Science, Crystal Engineering and MaterialsXin Xu, Dong Chen, Hongzhen Li, Mi Yan, Ying Xiong, Haixia Zhao, Rong Xu. Akihito Kiguchiya, Reiko Teraoka, Toshiyasu Sakane, Etsuo Yonemochi. Dimenhydrinate is used to treat or prevent nausea, vomiting, and dizziness associated with motion sickness.. Dimenhydrinate may also be used for purposes not listed in this medication guide. You have to login with your ACS ID befor you can login with your Mendeley account.Crystal Structure Determination of Dimenhydrinate after More than 60 Years: Solving Salt–Cocrystal Ambiguity via Solid-State Characterizations and Solubility StudyDepartment of Chemistry and Materials Science, Tokyo Institute of Technology, 12-1-H62, Ookayama 2, Meguro, Tokyo 152-8551, JapanSchool of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo 142-8501, JapanGraduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, JapanMichal Hušák, Alexandr Jegorov, Jan Rohlíček, Andrew Fitch, Jiří Czernek, Libor Kobera, Determining the Crystal Structures of Peptide Analogs of Boronic Acid in the Absence of Single Crystals: Intricate Motifs of Ixazomib Citrate Revealed by XRPD Guided by ss-NMR. In this study, we have attempted to determine the structure of DIM through single crystal X-ray structure analysis and confirmed the salt–cocrystal ambiguity. Acta Crystallographica Section E Crystallographic CommunicationsOkky Dwichandra Putra, Daiki Umeda, Yuda Prasetya Nugraha, Takayuki Furuishi, Hiromasa Nagase, Kaori Fukuzawa, Hidehiro Uekusa, Etsuo Yonemochi. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Jiri Brus, Jiri Czernek, Libor Kobera, Martina Urbanova, Sabina Abbrent, and Michal Husak .
Crystal structure evolution of an energetic compound dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate induced by solvents. Drug‑Drug and Drug‑Nutraceutical Cocrystal/Salt as Alternative Medicine for Combination Therapy: A Crystal Engineering Approach. Paolo Cerreia Vioglio, Michele R. Chierotti, Roberto Gobetto. Please reconnect without permission from the American Chemical Society. Diphenhydramine is a first generation antihistamine and ethanolamine with sedative and anti-allergic properties.