In 3 women who received 0.25 to 0.37 mg/kg/minute, propofol was detectable in colostrum, but not quantifiable because of technical difficulties. They were given doses of propofol that targeted a serum concentration of 6.5 mcg/L for induction and stopped as xenon anesthesia was started. Propofol: minimal amounts (0.025%) of propofol are transferred to breast milk.
2010;10:1. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Postpartum oxytocin levels in the nonmedicated vaginal delivery group were higher than in the general and spinal anesthesia groups. Propofol (category B) In the pregnant patient, it is recommended that propo-fol be administrated by a trained anesthesia provider be-cause of its narrow therapeutic index and the importance of close monitoring.
Select one or more newsletters to continue. In one patient, colostrum level was 0.33 mg/L at 4 hours after the bolus; a second patient had levels of 0.74 mg/L at 5 hours and 0.048 mg/L at 8 hours after the bolus; a third patient had a colostrum level of 0.036 mg/L at 6 hours after the bolus.
Gastrointest Endosc.
A single dose was given immediately after clamping of the umbilical cord. DOI: 10.7546/CRABS.2018.07.17.
Her milk propofol level was 0.13 mg/L at 300 minutes after extubation.
C R Acad Bulg Sci .
The first milk she pumped 8 hours after the procedure was green in color.
The other mother received a total of 443 mg of propofol intravenously and had an operative time of 35 minutes. J Clin Diagn Res.
Colostrum levels averaged 0.17 mg/L (range 0.14 to 0.24 mg/L) in 3 of the women 4 hours after the dose and 0.14 mg/L (range 0.089 to 0.19 mg/L) in 4 of the women 8 hours after the dose. Both propofol and metoclopramide have caused green urine. Operation times ranged from 35 to 45 minutes. Clin Pharmacol Ther.
The green color faded and was absent by postoperative day 4 when she resumed breastfeeding. Guidelines for endoscopy in pregnant and lactating women. [PMC free articleKarasu D, Yilmaz C, Ozgunay SE et al. [5] Two case reports noted green discoloration of breastmilk after nursing mothers received propofol.Four women received a single intravenous bolus dose of propofol 2.5 mg/kg prior to cesarean section.
Maternal Levels.Five women who had undergone general anesthesia with propofol intravenously shortly after delivery had colostrum propofol levels measured.
Thirty hours later, propofol was detected in a milk sample at a concentration of 24 mcg/L, completely as unconjugated propofol. Breastfeeding Studies in women breastfeeding have demonstrated harmful infant effects.
This corresponds to 0.2% of the maternal weight-adjusted dosage. This is not a concern even when propofol is used by infusion for maintenance of anaesthesia. In the same report, 3 women received a bolus dose of propofol 2.5 mg/kg followed by a continuous infusion of 5 mg/kg/hour.
Available for Android and iOS devices.Vargo JJ, Delegge MH, Feld AD et al. 2012;76:18-24.
[PubMedBhaskara B, Dayananda VP, Kannan S et al. The authors estimated that the infants would receive an average of 0.0052 mg/kg in the 24 hours after a single dose of propofol. [PubMedDailland P, Cockshott ID, Didier Lirzin J et al. Ann Fr Anesth Reanim. Assuming that undetectable milk levels had the concentration of the assay limit, the average dosage excreted in milk was 0.27% of maternal weight … [3] The infants of mothers not undergoing a surgical procedure might receive a greater dose of propofol in breastmilk, but it would be unlikely to be a large dose.A woman received 474 mg of propofol by controlled infusion during a procedure to terminate an ectopic pregnancy. Effects of different anesthesia protocols on lactation in the postpartum period. Two mothers who were breastfeeding their infants were given propofol doses that targeted a serum concentration of 6.5 mcg/L for anesthesia induction. Propofol was stopped as xenon anesthesia was started.