A randomized, double‐blind, placebo‐controlled studyPedal edema—not all dihydropyridine calcium antagonists are created equalCalcium channel blocker‐related peripheral edema: can it be resolvedCalcium antagonists as first‐line antihypertensive agents: a placebo‐controlled, comparative trial of isradipine and nifedipineA multicenter comparison of isradipine and felodipine in the treatment of mild‐to‐moderate hypertension[Circadian antihypertensive action and tolerability of a sustained‐release form of isradipine in an intra‐individual comparison with nitrendipine]The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease, Pharmacologic and Therapeutic Considerations in Hypertension Therapy With Calcium Channel Blockers: Focus on Verapamil, Search for other works by this author on:
Plendil (felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.
Innate immune mechanisms of arterial hypertension and autoimmune disease
Fetal Considerations: There are no adequate reports or well-controlled studies in human fetuses.
Felodipine-associated gingival enlargement has been reported in a patient with type 2 diabetes [6].The changes resolved after withdrawal of felodipine and control of the diabetes, and there were further improvements after scaling and root planing and instruction about oral hygiene. On average, subjects receiving a daily dose of amlodipine 10 mg were older (57.4 vs. 53.1 years), heavier (body mass index, 31 vs. 27), with a higher average serum creatinine value (1.2 vs. 1.5 mg/dL) and required more drugs to control their hypertension than was the case for those receiving amlodipine 5 mg/d: 81% of subjects were receiving adjuvant therapy to control BP (43% received one additional drug and 38% received two additional drugs).
John M. Dopp, Michael E. Ernst, Kevin C. Dellsperger, Bradley G. Phillips, P-267: Comparison of amlodipine and felodipine on 24-hour ambulatory blood pressure in hypertensive patients, Amlodipine and felodipine are often used interchangeably on hospital formularies for the treatment of hypertension.
Mean 24-hour ABP was 104±7 mmHg at baseline and decreased at 1, 4, and 8 weeks of amlodipine to 103±7, 100±7 and 95±6 mmHg, respectively (p<0.05). Adjuvant antihypertensive therapy was allowed, provided the drugs and their respective doses remained stable during the study. This greater anti‐hypertensive effect, particularly as related to SBP, was particularly evident among subjects who had been switched from amlodipine 10 mg.The superior antihypertensive response to controlled‐release isradipine 10 mg is important in that 81% of the 10 mg/d subjects were using three medications during the run‐in period and their mean SBP was higher than that seen in the 5 mg/d group. Other subject characteristics are presented in Table I. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription. BP was measured at 2‐week intervals during the controlled‐release isradipine treatment period.
First, these studies were not placebo‐controlled and a placebo‐effect may have entered into play; however, the fact that BP rose once again when patients reverted back to amlodipine (from controlled‐release isradipine) makes a placebo effect less likely.
Although these agents possess similar potencies and side effect profiles, direct comparisons are limited.
Felodipine decreases placental blood flow and prolongs parturition in rabbits.
Patients (n=24) randomized to amlodipine had a sitting BP of 151±12/93±8 mmHg prior to randomization.
Compare Amlodipine vs Norvasc head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Amlodipine seems to be more effective than felodipine when the drugs are compared in the same dose, with regard to the effect on clinic BP 24 h after dosing and to ambulatory BP during the night. Side effects were similar in both groups.