Epub 2018 Sep 24.Turk Kardiyol Dern Ars. However, there are variations in the properties of thiazide-related medications and few studies have compared A systematic review and meta-analysis of 14 head-to-head randomized controlled trials contrasting two or three of the diuretics HCTZ, CTDN, and INDAP located no trials comparing CTDN with INDAP and all trials lacked cardiovascular events as outcomes. This systematic review retrieved 9765 publications, and from these, it identified 14 randomized trials with 883 patients comparing HCTZ with INDAP and chlorthalidone on antihypertensive potency or metabolic effects. Each trial was then classified by relative dose level: HCTZ higher (HCTZ dose higher than INDAP or CTDN dose), INDAP higher (INDAP dose higher than HCTZ dose), CTDN higher (CTDN dose higher than HCTZ dose), and dose equivalent (drugs given at the same dose in the 2 arms).Data analyzed were mean effect, SD, and number of patients, n, in each arm. Where necessary, the SD was computed as SE times nSensitivity analyses were (1) a leave-one-trial-out analysis, (2) analysis of low- versus high-bias trials, (3) analysis of trials with background versus no background drug, (4) analysis with follow-up >4 weeks versus ≤4 weeks, (5) use of a 2-level classification for INDAP (1.25/2.5) rather than the 3-level classification (1.25/2.5/5), (6) use of the single most precise study,The search yielded 9765 references (Figure S1) of which were 14 eligible trials: 10 with HCTZ–INDAP comparisons of SBP, 3 with HCTZ–CTDN comparisons of SBP, and 9 with HCTZ–INDAP comparisons of metabolic parameters (CAD indicates coronary artery disease; CHF, congestive heart failure; CKD, chronic kidney disease; CTDN, chlorthalidone; CVD, cardiovascular disease; DBP, diastolic blood pressure; DM, diabetes mellitus; HCTZ, hydrochlorothiazide; INDAP, indapamide; MI, myocardial infarction; NA, not available; SBP, systolic blood pressure, and SR, sustained release.†Not relevant. 100 Thiazide and thiazide-like diuretics are cornerstone treatments for hypertension. Indapamide should be used with caution in patients with renal impairment as it may induce azotemia in patients with severe renal insufficiency. organization.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension.2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8).Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research.Is chlorthalidone better than hydrochlorothiazide in reducing cardiovascular events in hypertensives?National Institute for Health and Clinical ExcellencePreferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.Association between analytic strategy and estimates of treatment outcomes in meta-analyses.Biochemical changes in black and Indian hypertensive patients on diuretic therapy.A double-blind, randomized, placebo-controlled comparison of the metabolic effects of low-dose hydrochlorothiazide and indapamide.A comparison of indapamide SR 1.5 mg with both amlodipine 5 mg and hydrochlorothiazide 25 mg in elderly hypertensive patients: a randomized double-blind controlled study.Comparative trial of indapamide and hydrochlorothiazide in essential hypertension, with forearm plethysmography.Comparative metabolic effects of hydrochlorothiazide and indapamide in hypertensive diabetic patients receiving ACE inhibitor therapy.Comparison between the effects of indapamide and hydrochlorothiazide on creatinine clearance in patients with impaired renal function and hypertension.Indapamide or hydrochlorothiazide in hypertensive patients resistant to treatment with an angiotensin-converting enzyme inhibitor.Indapamide in the treatment of essential arterial hypertension: results of a controlled study.Hypertension in elderly patients.
Correspondence to George C. Roush, University of Connecticut School of Medicine Internal Medicine, St. Vincent's Medical Center, 2800 Main St, Bridgeport, CT 06606.
2015 May;65(5):1041-6. doi: 10.1161/HYPERTENSIONAHA.114.05021. Thiazide-related diuretics are recommended as first-line treatment in most hypertension guidelines and have been shown to be especially beneficial in resistant and salt-sensitive forms of hypertension. RESULTS Nineteen relevant papers with 21 comparisons were found. Close more info about HCTZ vs. Indapamide and Chlorthalidone: Head-to-Head Trials Reviewed Epub 2020 Feb 1.Martins VM, Helal L, Ferrari F, Bottino LG, Fuchs SC, Fuchs FD.Trials. Unable to load your delegates due to an error Indapamide diuresis may induce hepatic encephalopathy in some patients with severe liver disease.
Am Heart J 2014; 168 : 446–456. All thiazide-based diuretics have been reported in at least one trial showing … 2015 Mar;11(2):203-17. doi: 10.2217/fca.14.83.Cardiol Rev.
Epub 2015 Mar 2.Cardiol Rev. use prohibited.
2020 Aug 24;9(1):195. doi: 10.1186/s13643-020-01457-9.Integr Blood Press Control. 2020 Jun;9(1):139-152. doi: 10.1007/s40119-020-00162-x.
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This site uses cookies. Chlorthalidone, indapamide, and HCTZ have similar effects on serum potassium. 2018 Oct;20(10):1507-1515. doi: 10.1111/jch.13386. Mental status monitoring is recommended in patients with liver impairment. Please enable it to take advantage of the complete set of features! In another commentary, attention was focused on chlorthalidone as a potential substitute for HCTZ. 2019 Nov;131(Suppl 6):489-590. doi: 10.1007/s00508-019-01565-0. Despite this fact, HCTZ is … Atypon 2020 Aug 5;13:83-93. doi: 10.2147/IBPC.S223334.
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However, its natriuretic and aquaretic effects are dose related. Close more info about HCTZ vs. Indapamide and Chlorthalidone: Head-to-Head Trials Reviewed 2015 May;65(5):983-4. doi: 10.1161/HYPERTENSIONAHA.115.05138. Name must be less than 100 characters