The combination should be avoided unless the benefit outweighs the increased risk of systemic glucocorticoid side-effects.Co-treatment with other potent CYP3A inhibitors, including cobicistat-containing products, is expected to increase the risk of systemic side-effects.
However, if you don't notice any improvement in your symptoms after four to six weeks of using the drops, you should consult your doctor.Medicines and their possible side effects can affect individual people in different ways. **There have also been cases of nasal septal perforation following the use of intranasal corticosteroids. In assigning adverse event frequencies, the background rates in placebo groups in clinical trials were not taken into account, since these rates were generally comparable to or higher than those in the active treatment group.Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.Hypersensitivity reactions, anaphylaxis/anaphylactic reactions, bronchospasm, rash, oedema of the face and mouth*Nasal dryness, nasal irritation, throat dryness, throat irritation*As with other intranasal products dryness and irritation of the nose and throat, and epistaxis may occur.
For full therapeutic benefit regular usage is essential. Advice on using Flixonase nasule drops, containing the corticosteroid fluticasone, to treat nasal polyps, including how to use flixonase nasal drops It allows continued monitoring of the benefit/risk balance of the medicinal product. The dose should be divided between the nostrils by either counting approximately 6 drops into each nostril or by holding the dimpled sides of the container and squeezing once into each nostril (one squeeze delivers approximately half the dose).Full instructions for use are given in the patient information leaflet.Flixonase Nasule Drops are contra-indicated in patients with a history of hypersensitivity to the active substance or to any of the excipients listed in section 6.1.Local infection: Infections of the nasal airways should be appropriately treated but do not constitute a specific contra-indication to treatment with Flixonase Nasule Drops.Unilateral polyposis rarely occurs, and could be indicative of other conditions. Just because a side effect is stated here doesn't mean that all people using these nose drops will experience that or any side effect.If corticosteroid nasal drops are used in high doses for long periods of time, they do have the potential to cause side effects similar to those associated with corticosteroids taken by mouth, such as mental health problems, slowed growth in children and adolescents, and decreased functioning of the adrenal glands (glands that produce natural steroid hormones). In addition, consideration should be given to referring the patient to a paediatric specialist, if growth is retarded.It is possible that long term treatment with higher than recommended doses of nasal corticosteroids could result in clinically significant adrenal suppression. Systemic bioavailability for the nasal drop formula is extremely low (mean value 0.06 %).Following intravenous administration the pharmacokinetics of fluticasone propionate are proportional to the dose, and can be described by three exponentials.Absolute oral bio-availability is negligible (<1 %) due to a combination of incomplete absorption from the gastro-intestinal tract and extensive first pass metabolism.Fluticasone propionate is extensively distributed within the body (Vss is approximately 300 litre). Fluticasone also comes as nasal drops that shrink nasal polyps.
This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Cases of Cushing's syndrome and adrenal suppression have been reported.
Your doctor can give you more advice about this.Read the leaflet that comes with the medicine or talk to your doctor or pharmacist if you want any more information about the possible side effects of Flixonase nasule drops.