Excessive presence or absence of dietary folic acid may regulate MTX metabolism, possibly leading to unexpected adverse reactions. We could confirm the pomelotacrolimus interaction, which we discovered in a case study, quantitatively. Lien HC, Sun WM, Chen YH, et al. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. The inhibitory effect of 100% pomelo juice disappeared 3 days after intake. 2012 Apr 25;27(2):242-7. Egashira, Kanoko ; Sasaki, Hitoshi ; Higuchi, Shun title = "Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats", abstract = "Tacrolimus is a well-known potent immunosuppressant agent, which has various drug-drug or food-drug interactions. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. Zhang W, Lim L‐Y. 2012 Oct 24;60(42):10578-84. On the other hand, the tacrolimus blood concentrations of the rats pre-treated with 50% pomelo juice were not significantly different from those pre-treated with water. We could confirm the pomelotacrolimus interaction, which we discovered in a case study, quantitatively. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. Drug Metab Pharmacokinet. The tacrolimus blood concentrations of the rats pre-treated with 100% pomelo juice were significantly higher than those pre-treated with water. So, we investigated the effect of pomelo after its administration for one day or 3 consecutive days on the pharmacokinetics of tacrolimus in rats. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in ratsFood-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in ratsFood-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats Effects of spice constituents on P‐glycoprotein‐ mediated transport and CYP3A4‐mediated metabolism in vitro. On the other hand, the tacrolimus blood concentrations of the rats pre-treated with 50% pomelo juice were not significantly different from those pre-treated with water. The AUC values of tacrolimus in the rats pre-treated with grapefruit juice, ginger juice, and turmeric juice were significantly larger than those pre-treated with water. Drug Metab Pharmacokinet. We also confirmed the effects of grapefruit, turmeric, and ginger. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration.
Egashira K, Sasaki H, Higuchi S, Ieiri I. Food-drug interaction of tacrolimus with pomelo, ginger, and turmeric juice in rats. We newly found the influence of turmeric and ginger on tacrolimus pharmacokinetics, comparable to pomelo.AB - Tacrolimus is a well-known potent immunosuppressant agent, which has various drug-drug or food-drug interactions. For example, methotrexate (MTX), the anchor drug in the therapeutic strategy against RA, is an antifolate agent. The inhibitory effect of 100% pomelo juice disappeared 3 days after intake. 2008;36(7):1283‐1290. 11. Previously, we found a renal transplant recipient who increased tacrolimus blood concentrations after ingestion of pomelo as a rare case. Even low concentration of pomelo juice could enhance the blood concentrations of tacrolimus by repeated administration.