The dose should be increased to 100 mg once daily based on blood pressure response In patients with mild-to-moderate hepatic impairment the recommended starting dose of losartan potassium is 25 mg once daily. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure:Coadministration of losartan with other drugs that raise serum potassium levels may result in hyperkalemia. In addition, blood pressure reductions in both treatment groups were consistent between Black and non-Black patients. side effects include: Because the study was designed to achieve equal blood pressure control in both groups, other antihypertensive agents (diuretics, calcium-channel blockers, alpha- or beta-blockers, and centrally acting agents) could be added as needed in both groups. Peak (6 hour) effects were uniformly, but moderately, larger than trough effects, with the trough-to-peak ratio for systolic and diastolic responses 50 to 95% and 60 to 90%, respectively.Addition of a low dose of hydrochlorothiazide (12.5 mg) to losartan 50 mg once daily resulted in placebo-adjusted blood pressure reductions of 15.5/9.2 mmHg.Analysis of age, gender, and race subgroups of patients showed that men and women, and patients over and under 65, had generally similar responses. If symptomatic hypotension should occur, supportive treatment should be instituted.Neither losartan nor its active metabolite can be removed by hemodialysis.Losartan potassium is an angiotensin II receptor blocker acting on the ATLosartan potassium, USP is white to off-white powder with a molecular weight of 461.01. I thought high blood pressure was a strong issue for me but now I realize blood pressure isn’t the problem.
The principal pharmacokinetic parameters in adults and children are shown in the table below.The bioavailability of the suspension formulation was compared with losartan tablets in healthy adults. Losartan works on a hormone called angiotensin II to lower blood pressure and may also improve kidney function in some people. Aldosterone plasma concentrations fall following losartan administration. : 1-877-993-8779.Call your doctor for medical advice about side effects. Children who weighed <50 kg received 2.5, 25 or 50 mg of losartan daily and patients who weighed ≥50 kg received 5, 50 or 100 mg of losartan daily. Almost all of the patients (96.6%) had a history of hypertension, and the patients entered the trial with a mean serum creatinine of 1.9 mg/dL and mean proteinuria (urinary albumin/creatinine) of 1808 mg/g at baseline.The primary endpoint of the study was the time to first occurrence of any one of the following events: doubling of serum creatinine, end-stage renal disease (ESRD) (need for dialysis or transplantation), or death.
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Treatment with losartan potassium also reduced the occurrence of sustained doubling of serum creatinine by 25% and ESRD by 29% as separate endpoints, but had no effect on overall mortality (see Table 4).The mean baseline blood pressures were 152/82 mmHg for losartan potassium plus conventional antihypertensive therapy and 153/82 mmHg for placebo plus conventional antihypertensive therapy. In addition to the active carboxylic acid metabolite, several inactive metabolites are formed. Adult Hypertension.