Increased Mortality in Elderly Patients with Dementia-Related PsychosisElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Available for Android and iOS devices. Loxapine may increase the risk of death in older adults with dementia-related conditions.To make sure loxapine is safe for you, tell your doctor if you have:Follow all directions on your prescription label. The possibility of occurrence of extrapyramidal symptoms and/or convulsive seizures should be kept in mind.
Whether antipsychotic drug products differ in their potential to cause tardive dyskinesia is unknown.Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.Other drugs may interact with loxapine, including prescription and over-the-counter medicines, Your pharmacist can provide more information about loxapine.Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect.
white/yellow, imprinted with Watson 370, 10 mg. Loxapine 10 mg-WAT. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Heart failure As adjunct: Initial: 2.5 mg once daily, may increase up to 20-40 mg at 4-week interval according to clinical response.Post MI Initial: 5 mg once daily within 24 hours of the onset of symptoms, followed by 5 mg after 24 hours; then 10 mg once daily for 6 weeks.
The usual therapeutic and maintenance range is 60 mg to 100 mg daily.
Patients with severe neutropenia (absolute neutrophil count < 1000/mm Loxapine should be used with extreme caution in patients with a history of convulsive disorders since it lowers the convulsive threshold. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Overdose symptoms may include weak or shallow breathing, Loxapine may impair your thinking or reactions.
Taking loxapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects.
Perinatal studies have shown renal papillary abnormalities in offspring of rats treated from mid-pregnancy with doses of 0.6 mg/kg and 1.8 mg/kg, doses which approximate the usual human dose but which are considerably below the maximum recommended human dose.The extent of the excretion of Loxapine or its metabolites in human milk is not known. The incidence of sedation has been less than that of certain aliphatic phenothiazines and slightly more than the piperazine phenothiazines. Max: 80 mg/day. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
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Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias).The diagnostic evaluation of patients with this syndrome is complicated. and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). 10 Aluminum Lake, FD&C Blue No. No embryotoxicity or teratogenicity was observed in studies in rats, rabbits, or dogs although, with the exception of one rabbit study, the highest dosage was only two times the maximum recommended human dosage and in some studies it was below this dose. These symptoms are usually not severe and can be controlled by reduction of Loxapine dosage or by administration of antiparkinson drugs in usual dosage.Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Avoid analeptics, such as pentylenetetrazol, which may cause convulsions.