Analysis of delayed ischemic deficits, many of which result from spasm, showed a significant reduction in spasm-related deficits. Both studies showed significantly fewer severe deficits due to spasm in the Nimodipine group; the second (French) study showed fewer spasm-related deficits of all severities. Nimodipine is called a calcium channel blocker. Do not store in the bathroom. Nimodipine is over 95% bound to plasma proteins. A causal relationship has not been established. Nimodipine 60 mg every four hours is administered to all patients with aneurysmal subarachnoid hemorrhage, ideally within four days of SAH.The typical dose is 60 mg every four hours by mouth or nasogastric tube.Nimodipine must be given orally or by nasogastric tube because inadvertent intravenous administration has been associated with serious adverse events, including death. https://www.webmd.com/drugs/2/drug-10951/nimodipine-oral/details Available for Android and iOS devices. However, whether or not the arteriographic methodology utilized was adequate to detect a clinically meaningful effect, if any, on vasospasm is unknown.In man, Nimodipine is rapidly absorbed after oral administration, and peak concentrations are generally attained within one hour. Moderate and weak CYP3A4 inhibitors include amprenavir, aprepitant, atazanavir, amiodarone, alprozalam, cyclosporine, cimetidine, erythromycin, fluconazole, fluoxetine, isoniazid, oral contraceptives, quinuprestin/dalforpristin, and valproic acid.Blood pressure should be carefully monitored, and dose adjustment of the blood pressure lowering drug(s) may be necessary.In a two-year study, higher incidences of adenocarcinoma of the uterus and Leydig-cell adenoma of the testes were observed in rats given a diet containing 1800 ppm Nimodipine (equivalent to 91 to 121 mg/kg/day Nimodipine) than in placebo controls. The trials used doses ranging from 20–30 mg to 90 mg every 4 hours, with drug given for 21 days in 3 studies, and for at least 18 days in the other. The differences were not statistically significant, however, and the higher rates were well within historical control range for these tumors in the Wistar strain. Do not double the dose to catch up.Store at room temperature away from light and moisture. Patients who received Nimodipine in clinical trials for other indications reported flushing (2.1%), headache (4.1%) and fluid retention (0.3%), typical responses to calcium channel blockers. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment.This survey is being conducted by the WebMD marketing sciences department.All information will be used in a manner consistent with the WebMD A parenteral syringe can be used to extract the liquid inside the capsule, but the liquid should always be transferred to a syringe that cannot accept a needle and that is designed for administration orally or via a naso-gastric tube or PEG. Nimodipine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Nimodipine and/or its metabolites have been shown to appear in rat milk at concentrations much higher than in maternal plasma. Dosage should be reduced to one 30 mg capsule every 4 hours with close monitoring of blood pressure and heart rate; if necessary, discontinuation of the treatment should be considered.Strong inhibitors of CYP3A4 should not be administered concomitantly with Nimodipine (see Manufactured for: The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Nimodipine increases cerebral perfusion, particularly in poorly perfused areas, by arterial dilatation, an effect which is proportionately greater in smaller than in larger vessels.