Mefenamic Acid suspension contains mefenamic acid which is a non-steroidal anti-inflammatory drug (NSAID). The maximum daily dose of acetaminophen is 4 g. Liver failure has been observed at doses as low as 6 g per day. DOSAGE AND ADMINISTRATION; Oral : Children above 6 months: Mefenamic acid and paracetamol are recommended in the following dosage: Mefenamic acid: 25 mg/kg daily in divided doses, or 4-6.5 mg/kg/dose every 8 hours. <>
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By mouth. Dosage form and strength Centamol Plus suspension is available bottle of 60ml with a measuring cup. Pains connected with rheumatoid arthritis. -Following initial dose: 250 mg orally every 6 hours as needed-Duration of therapy: Usually not to exceed 1 week Use: For the relief of acute pain.
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N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of acetaminophen toxicity.For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.For temporary relief of fever, minor aches, and pains.We are a growing pharmaceutical company, committed to increase access to high-quality healthcare by developing, producing and marketing affordable generic drugs in Domestic as well as International Markets. endobj
Mefenamic acid is widely seud by practising pediatricinas.
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It is licensed as an antiinflammatory analgesic for the symptomatic relief of rheumatoid arthritis, osteoarthritis and pain including muscular, dental pain, headaches and pyrexia in children.
500 mg 3 times a day.
Peak Plasma Time: 2-4 hr (1 g dose); reached by the second day of administration (1 g dose, 4x daily) Peak Plasma Concentration: 10 mcg/mL (1 g dose); 20 mcg/mL (1 g dose, 4x daily) Protein Bound: Extensive.
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For Adult. 0000007891 00000 n
At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is excreted by the kidneys.
has been developed and validated for simultaneous estimation of Paracetamol and Mefenamic acid in suspension. Clinical particulars 3.1 Therapeutic indication Centamol Plus suspension is licensed for treatment of pain and fever in children.
Abdominal pain.
Only a small portion is excreted in unchanged in urine or oxidized via the hepatic cytochrome P450 enzyme system (CYP2E1).
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Anorexia. 0000014478 00000 n
It is found to be highly effective in controlling high fe-ver. High doses of acetaminophen may cause glutathione depletion, accumulation of NAPQI and hepatic necrosis. You shouldn’t take mefenamic acid for longer than seven days. No Interactions Found. 0000010052 00000 n
500 mg 3 times a day.
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0000001233 00000 n
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Mefenamic acid is a nonsteroidal antiinflammatory agent with analgesic properties, and a demonstrable antipyretic effect. endobj
Gastritis.
Usual Pediatric Dose for Dysmenorrhea. Dosage of Mefenamic and paracetamol suspension. 0000009106 00000 n
Child dosage (ages 14–17 years) The first dose is 500 mg. After that, take 250 mg every six hours as needed. �i���l@��Y&��h�3�@�b�D�D;��oܪj6�&�4�]쑩��b��Tu�|���U>�ػw�Ӫ�����q����r�����ay~����*��������0{���#g\����+�"��3�$�L�P��Ͷ�_E��������L��L�K6���~}�� Oral : Children above 6 months: Mefenamic acid and paracetamol are recommended in the following dosage: Mefenamic acid: 25 mg/kg daily in divided doses, or 4-6.5 mg/kg/dose every 8 hours. Nausea. Next: Adverse Effects >10%.
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Conjugates are then excreted by the kidneys.
6 months to 1 year: 5 ml to be administered three times daily.