Finally, we observed substantial quantitative heterogeneity across the studies, but the small number of studies limited our ability to explore possible sources of this variability. 0000041785 00000 n
‘It is indicated for use as monotherapy or in combination therapy with metformin, a sulfonylurea, or insulin in the treatment of type 2 diabetes.’ More example sentences ‘Both the systematic review and meta-analyses confirmed the superiority of combination therapy to inhaled corticosteroids monotherapy.’ 0000231235 00000 n
However, when a combination of metformin and sulfonylurea was prescribed in the same trial for glycemic control, there was a significant increased risk of diabetes-related death and all-cause mortality rather than a beneficial effect, a finding attributed by the investigators to be due to chance (A recent systematic review of clinical trials of diabetes therapies noted that data on long-term outcomes were not available in most clinical trials (Given these inconsistencies in the literature and the lack of clinical trials assessing the long-term effects of combination therapy of sulfonylureas and metformin, we conducted a meta-analysis of observational studies to examine the association between combination therapy of sulfonylureas and metformin and risk of CVD and all-cause mortality.A literature search of the MEDLINE database (from January 1966 through July 2007) was conducted using the medical subject headings “diabetes mellitus, type 2;” “drug therapy, combination;” “drug combinations;” “sulfonylurea compounds;” “acetohexamide;” “chlorpropamide;” “tolbutamide;” “tolazamide;” “glyburide;” “glipizide;” “biguanides;” and “metformin” and keyword “glimepiride.” The search was restricted to include studies conducted only in human subjects.
Glipizide and Metformin combination is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Please check with a physician if you have health questions or concerns. 0000156231 00000 n
Ø Sulfonylureas eg. Glipizide belongs to a class of drugs known as sulfonylureas. 0000028189 00000 n
The protocol was approved by the institutional review board at Wake Forest University Baptist Medical Center. 0000041512 00000 n
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Adult Dosage: Give glyburide and metformin hydrochloride tablets in divided doses, twice daily, with meals. ;
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2007; 100: 395-404 Classification of Drugs That May Lead to Weight Gain When necessary, SEs were derived from the CIs provided in each original study.The primary data for time to event analyses were not available for the combined cohort. 0000006143 00000 n
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(In our analysis, we found a relatively greater association with fatal and nonfatal CVD events than in fatal events alone, suggesting that the incidence of CVD events may be increased with combination therapy, but there may have been a lower case-fatality rate. 0
It is also unclear to what extent certain biases and methodological limitations, such as residual confounding, might exist in the studies included in this meta-analysis, since the majority of these studies were retrospective database analyses. QJM. How it works. 0000111646 00000 n
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Hypoglycemia may increase the risk of cardiovascular abnormalities, including ischemia and a propensity to cause arrhythmias (Although a meta-analysis is not the best way to test the efficacy and safety of such a combination of treatments, it is highly unlikely that a large-scale clinical trial to test this hypothesis will be carried out. 0000018378 00000 n
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Due to the progressive nature of type 2 diabetes, many patients are put on combinations of oral antihyperglycemic agents in order to meet glycemic goals. To determine the impact of dipeptidyl peptidase-4 inhibitor (DPP4i) on the risk of major cardiocerebrovascular and renal outcomes compared with sulfonylurea (SU) combined with metformin in patients with type 2 diabetes from a population-based cohort. 0000172502 00000 n
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at System.Runtime.Remoting.Proxies.RealProxy.PrivateInvoke(MessageData& msgData, Int32 type)
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This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.Thank you for your interest in spreading the word about Diabetes Care.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. These results may help clarify the conflicting findings of several large observational studies that examined the effect of combination therapy with metformin and sulfonylureas on the risk of CVD events among patients with type 2 diabetes, while the association of this combination with all-cause and cardiovascular mortality remains obscure.Due to the progressive nature of type 2 diabetes, many patients are put on combinations of oral antihyperglycemic agents in order to meet glycemic goals. 0000017066 00000 n
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Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. 0000009794 00000 n