Fluconazole is designated chemically as 2,4-difluoro-α,α 1-bis(1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with an empirical formula of C 13 H 12 F 2 N 6 O and molecular weight of …
Patients have rarely developed exfoliative cutaneous reactions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, during treatment with fluconazole. Fluconazole clearance is proportional to creatinine clearance. The major route of excretion is renal, with approximately 80% of the administered dose appearing in the urine as unchanged medicinal product. Store in the original package.Blister PVC/Aluminium foil, Packs of 7 capsules in a cartonSage House, 319 Pinner Road, North Harrow, Middlesex, HA1 4HF, UKTo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. Interaction studies with antipyrine indicate that single or multiple doses of fluconazole 50 mg do not affect its metabolism. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.Please read our extensive post on Thrush and similar conditions by clicking the post link below;You can also find additional information on Thrush from the Talk to your doctor or pharmacist before taking FluconazoleTell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.Always take this medicine exactly as your doctor has told you. The following adverse reactions have been observed and reported during treatment with Fluconazole capsule with the following frequencies: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data). There are few pharmacokinetic data to support this posology in term newborn infants (see section 5.2).The same mg/kg dose as for infants, toddlers and children should be given every 72 hours A maximum dose of 12 mg/kg every 72 hours should not be exceeded The same mg/kg dose as for infants, toddlers and children should be given every 48 hours A maximum dose of 12 mg/kg every 48 hours should not be exceeded Fluconazole capsule may be administered either orally or by intravenous infusion, the route being dependent on the clinical state of the patient. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. In patients with fungal meningitis, fluconazole levels in the CSF are approximately 80% the corresponding plasma levels. The levels of fluconazole in saliva and sputum are similar to plasma levels. Ten of these patients were concomitantly receiving diuretics. If patients with invasive/systemic fungal infections develop rashes, they should be monitored closely and fluconazole discontinued if In rare cases anaphylaxis has been reported (see section 4.3). Regrowth of fingernails and toenails normally requires 3 to 6 months and 6 to 12 months, respectively. Fluconazole is a triazole antifungal agent. The mean half-life (hours) was 74 (range 44-185) on day 1 which decreased, with time to a mean of 53 (range 30-131) on day 7 and 47 (range 27-68) on day 13. Capsules contain lactose monohydrate. Fluconazole is a moderate inhibitor of the isozymes CYP2C9 and CYP3A4 (see section 4.5). Alfentanil: During concomitant treatment with fluconazole (400 mg) and intravenous alfentanil (20 μg/kg) in healthy volunteers the alfentanil AUC 10 increased 2-fold, probably through inhibition of CYP3A4.
• To reduce the incidence of recurrent vaginal candidiasis (4 or more episodes a year). Studies in animals have shown reproductive toxicity (see section 5.3).Fluconazole in standard doses and short-term treatments should not be used in pregnancy unless clearly necessary. Additional data were available from a compassionate use study.