In conclusion, the favorable pharmacokinetic and drug interaction profile of zonisamide, together with its broad spectrum of efficacy and good tolerability as determined across an excess of 2 million patient‐years exposure, support its use as an adjunctive agent in the treatment of refractory epilepsy.Please check your email for instructions on resetting your password.
Serious Interactions. Chemistry, biotransformation, and pharmacokineticsThe pharmacokinetic and pharmacodynamic consequences of the co‐administration of lamotrigine and a combined oral contraceptive in healthy female subjectsDrug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein bindingZonisamide and topiramate combination therapy: safety and tolerabilityClinical pharmacokinetics of new antiepileptic drugsPharmacokinetics of zonisamide in young and elderly subjectsPre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration, Evaluation of zonisamide for the treatment of focal epilepsy: a review of pharmacokinetics, clinical efficacy and adverse effects, Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy, Manufacturer advises avoid in children. However, zonisamide and topiramate are both weak inhibitors of carbonic anhydrase (Pharmacokinetic interactions between AEDs and oral contraceptive agents have received considerable attention in recent years and are of understandably substantial clinical significance. Different regimens were used to titrate the dose, but all patients randomised to take zonisamide were on 400 mg daily from the eighth week of the study.
Relevant drug–drug interaction studies have been reviewed (363 R).
Does Zonisamide Interact with other Medications?
Indeed, the interaction with enzyme‐inducing AEDs may be advantageous by permitting a more rapid attainment of steady‐state zonisamide concentrations. If you have a sulfa allergy. Drug–drug interactions Antiepileptic drugs. Severity of interaction: Severe Evidence for interaction: Theoretical. With increased incidence of renal stones, patients are encouraged to drink liberally.
Hepatic impairment: No data. Acetylation to N‐acetyl zonisamide accounts for a further 20% and around 15–30% of the parent drug is excreted unchanged in the urine (Formal assessment of zonisamide pharmacokinetics in special populations has not been performed but anecdotal reports suggest that CL/F is marginally elevated in children under the age of 15 years, leading to an increase in the weight‐adjusted dose requirement, as often seen with other AEDs (One of the principal pathways of zonisamide inactivation is reductive metabolism by CYP3A4. Serious interactions of zonisamide include: idelalisib; ivacaftor; nefazodone; Zonisamide has moderate interactions with at least 150 different drugs. = (273.15 to 313.15) K , The Toxicity of Newer and Lesser-Known Anticonvulsant Drugs, Aldehyde Oxidase and Its Role as a Drug Metabolizing Enzyme, The number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study, Antiepileptic drug therapy in the elderly: a clinical pharmacological review, An evaluation of zonisamide, including its long-term efficacy, for the treatment of focal epilepsy, Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction, Pharmacokinetics and Drug Interaction of Antiepileptic Drugs in Children and Adolescents, The Pharmacological Management of Lennox-Gastaut Syndrome and Critical Literature Review, A novel HPLC method for the determination of zonisamide in human plasma using microextraction by packed sorbent optimised by experimental design, Zonisamide Adjunctive Therapy in Intractable Childhood Epilepsy with Mitochondrial Respiratory Chain Complex Defects, Could Adult European Pharmacoresistant Epilepsy Patients Be Treated With Higher Doses of Zonisamide?, Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study, The safety and long-term efficacy of zonisamide as adjunctive therapy for focal epilepsy, Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations, A Case of Zonisamide-Induced Stevens-Johnson Syndrome, Zonisamide: Review of Recent Clinical Evidence for Treatment of Epilepsy, Use of Antiepileptic Drugs in Patients with Chronic Kidney Disease and End Stage Renal Disease, A simple and accurate liquid chromatography–tandem mass spectrometry method for quantification of zonisamide in plasma and its application to a pharmacokinetic study, What Are the Arguments For and Against Rational Therapy for Epilepsy?, Issues in Clinical Epileptology: A View from the Bench, Second-generation antiepileptic drugs and pregnancy: a guide for clinicians, Pharmacokinetic of Antiepileptic Drugs in Patients with Hepatic or Renal Impairment, Impact of Pregnancy on Zonisamide Pharmacokinetics in Rabbits, Safe Treatment of Seizures in the Setting of HIV/AIDS, Suivi thérapeutique pharmacologique de la primidone et du phénobarbital, Short-term efficacy and safety of zonisamide as adjunctive treatment for refractory partial seizures: A multicenter open-label single-arm trial in Korean patients, Therapeutic Drug Monitoring of Classical and Newer Anticonvulsants, A Practitioner’s Guide to Prescribing Topiramate for Adults with Intellectual Disabilities, A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities, A Practitioner’s Guide to Prescribing Zonisamide for Adults with Intellectual Disabilities, A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities, Zonisamide: its pharmacology, efficacy and safety in clinical trials, Moderate toxic effects following acute zonisamide overdose, The long-term retention of zonisamide in a large cohort of people with epilepsy at a tertiary referral centre, Drug safety evaluation of zonisamide for the treatment of epilepsy, Side Effects of Drugs Annual 32 - A worldwide yearly survey of new data and trends in adverse drug reactions and interactions, Suivi thérapeutique pharmacologique du zonisamide, A Clinical Guide to Epileptic Syndromes and their Treatment, Drug to Drug Interactions of Antiepileptic Drugs (AEDs): I. Interactions Between AEDs, Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients, Zonisamide: review of pharmacology, clinical efficacy, tolerability, and safety, Current awareness: Pharmacoepidemiology and drug safety,