Antimicrob Agents Chemother 1999; 43:1379. Gram-negative coverage comparable to ceftazidime but has better gram-positive coverage. You may need to take different antibiotics if you have Pseudomonas. Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis. Because of its anaerobic coverage, amoxicillin-clavulanate is an excellent drug for treating infections caused by human and animal bites. For example, tigecycline can cover MRSA, but it distributes rapidly into the tissues upon IV administration, so tigecycline is a poor choice for MRSA bacteremia. During this time it is common for the student to receive a somewhat overwhelming amount of information and little guidance on the relative clinical importance of the material. Best beta-lactam for IM administration. Antibiotics that Cover the Anaerobes (including Bacteroides fragilis) Zosyn (piperacillin & tazobactam); Augmentin (Amoxicillin & Clavulanate); Unasyn (Ampicillin & Sulbactam); Timentin (Ticarcillin & clavulanate) — Penicillins with beta-lactamase inhibitor* Cefepime is a zwitterion that rapidly penetrates gram-negative cells. One thing that can help when trying to list all the drugs that cover these organisms is to attempt to recall them using a structured approach, one class at a time.Antibiotics without activity versus either of the pathogens have not been included.NOTE: This general table is provided for study purposes only. For the treatment of Pseudomonas infections. Many pharmacy students are introduced to antimicrobial spectrum of activity basics through microbiology coursework. Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to expression of the PER-1 extended-spectrum beta-lactamase. One thing that can help when trying to list all the drugs that cover these organisms is to attempt to recall them using a structured approach, one class at a time. List of Antibiotics that can Cover Pseudomonas and/or MRSA. My current pet hate is the use of Teicoplanin to treat UTIs (see Teicoplanin blog...) but I also come across patients being treated for Pseudomonas spp. In addition aminoglycosides and fluoroquinolones are indicated as a “no” for MRSA, but they may be an option as part of combination therapy.Hopefully this visual will be helpful for learning about which antibiotics can cover Endimiani A, Luzzaro F, Pini B, et al. In 2013 the U.S. Center for Disease Control and Prevention (CDC) released a report on antibiotic resistance threats (available MRSA is such an important organism that the Infectious Diseases Society of America (IDSA) developed a clinical practice guideline (available The table below is sectioned into drug classes. It rarely causes problems in people with healthy lungs. Not all students will struggle with this, but many do and simple study lists can be a great way to refresh or highlight some of the important points.In an effort to provide an additional resource for learning antimicrobial spectrum basics, I have composed this article, which focuses on two of the most important pathogens in healthcare today: methicillin-resistant MRSA is a catalase-positive Gram positive cocci and facultative anaerobe. When doing empiric abx coverage, you want to think of covering the following as needed. Emergence of antibiotic-resistant Pseudomonas aeruginosa: comparison of risks associated with different antipseudomonal agents. Sometimes it seems doctors are just guessing or picking their … Fourth-generation cephalosporin. with Co-amoxiclav which has no activity against Pseudomonas spp., or an anaerobic infection being treated with both Co-amoxiclav AND Metronidazole when either alone would be enough.