Primary endpoint is insulin resistance. A common medication for treating gout, allopurinol, ... Corticosteroids may be used to treat severe attacks of gout but can lead to increased blood glucose levels whilst they are being taken. Glucose levels in tail blood were determined using a glucose meter (ACCU-CHEK; Roche, Mannheim, Germany). It has also been shown to decrease cardiovascular complications in a myriad of cardiovascular conditions.
Access to patient‐level data would have been particularly helpful for our subgroup analyses and to explain the heterogeneity among studies.
About allopurinol. Even when the results were restricted to the higher‐quality studies, the differences in systolic and diastolic BP was 3.3 mm Hg and 1.4 mm Hg, respectively.UA is produced by the degradation of the purine nucleotides, the last steps of this process being mediated by the enzyme xanthine oxidoreductase. It may be given to you for other reasons. Authors of the papers were individually contacted in case the data were unclear.The main outcome of the present analysis was reduction of BP (systolic/diastolic) from baseline to follow‐up.The study quality was evaluated according to the Jadad composite score,An intention‐to‐treat traditional meta‐analysis was performed in accordance with the recommendations from the Cochrane Collaboration, the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) Statement for randomized controlled trials, and Meta‐Analysis of Observational Studies in Epidemiology (MOOSE) statement for others. Compared with the control group, systolic BP decreased by 3.3 mm Hg (95% confidence interval [CI], 1.4–5.3 mm Hg; Uric acid (UA) is the end product of purine metabolism catalyzed by the enzyme xanthine oxidoreductase, which is frequently elevated in patients with gout. If you do not receive an email within 10 minutes, your email address may not be registered, I have read and accept the Wiley Online Library Terms and Conditions of UseHyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, JapanRelation between serum uric acid and risk of cardiovascular disease in essential hypertension.
Of particular relevance, in light of the data from Cardillo et al,There were important, although not unexpected, differences between the diabetic and the control group. Tell your The potential side effects vary from a minor rash to life‐threatening allopurinol hypersensitivity syndrome, reported in 0.38% of inpatients treated with allopurinol,This systematic review has several limitations. That raises acid levels and is also linked to insulin resistance.
We extracted characteristics of each study including baseline and follow‐up BP; baseline demographic patterns; known diagnosis of hypertension, hyperuricemia, or chronic kidney disease; type of study design; use of other antihypertensive agents; and total duration of follow‐up, among others. Subgroup analysis for changes in diastolic blood pressure with allopurinol use.In our analysis we found that allopurinol use was associated with a small but significant lowering of systolic BP by 3.3 mm Hg and diastolic BP by 1.3 mm Hg. All drugs may cause side effects. There was a significant decrease in the serum uric acid (UA) levels in the treatment group at the end of 6 months, 1 year, and 2 years with respect to base line. CI indicates confidence interval.The various subgroup analyses for the changes in the systolic and diastolic BP are presented in Subgroup analysis for changes in systolic blood pressure with allopurinol use. 2. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username