Amiodarone is a widely used class III antiarrhythmic drug used for the therapy of ventricular and supraventricular arrhythmias, among them atrial fibrillation. 2018 Oct 2;138(14):1402-1411. doi: 10.1161/CIRCULATIONAHA.117.031457.Harskamp RE, Teichert M, Lucassen WAM, van Weert HCPM, Lopes RD.Cardiovasc Drugs Ther. Epub 2018 Aug 20. Non-vitamin K antagonist oral anticoagulants with amiodarone, P-glycoprotein inhibitors, or polypharmacy in patients with atrial fibrillation: systematic review and meta-analysis.
It has a very high iodine content of 37.3% by weight, and about 3 mg of iodine (i.e., ∼200 times the RDA of 150 mcg) are released into the circulation per 100 mg of amiodarone.
Be aware that amiodarone has a long half-life (25–100 days); thus, interactions may occur for … 2013 Feb;36(2):61-7. doi: 10.1002/clc.22081. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services.A 73-year-old man with coronary artery disease, hypertension, and renal insufficiency presents with recurrent, symptomatic atrial fibrillation despite a well-controlled ventricular rate. 2019 Oct;33(5):615-623. doi: 10.1007/s10557-019-06907-8.Clin Cardiol. Avendano R, Romero J, Lupercio F, Diaz JC, Quispe R, Golive A, Natale A, Garcia MJ, Krumerman AK, Di Biase L.J Interv Card Electrophysiol. Register for 3 FREE subscriber-only articles each month.
Reduce the dose of warfarin by one-third to two-thirds if amiodarone is added, and monitor the international normalized ratio (INR) once a week for the first 7 weeks of concurrent treatment. Elsevier Science 2019; 73:515–521. 2020 Feb;49(2):294-303. doi: 10.1007/s11239-019-01962-2.Vogiatzis I, Papavasiliou E, Dapcevitch I, Pittas S, Koulouris E.Avendano R, Romero J, Lupercio F, Diaz JC, Quispe R, Golive A, Natale A, Garcia MJ, Krumerman AK, Di Biase L.J Interv Card Electrophysiol. The DOACs are P-glycoprotein (P-gp) and cytochrome p-450 (CYP3A4) substrates. The drug prevents the recurrence of life-threatening ventricular arrhythmias and produces a modest reduction of sudden deaths in high-risk patients. Copyright © 2018 Elsevier Inc. All rights reserved. Substantial research efforts and resources are being directed towards gaining detailed information about the mechanisms underlying AF, its natural course and effective treatments and new evidence is continuously generated and published. Please enable it to take advantage of the complete set of features! doi: 10.1016/j.jjcc.2018.12.018 Google Scholar Amiodarone is more effective than sotalol or propafenone in preventing recurrent atrial fibrillation in patients for whom a rhythm-control strategy is chosen.
Name must be less than 100 characters This site needs JavaScript to work properly. COVID-19 is an emerging, rapidly evolving situation. Clipboard, Search History, and several other advanced features are temporarily unavailable. Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. The ventricular rate of untreated AF often averages between 160–180 beats per minute (although this is typically slower in older people).
Epub 2017 May 9.Doucette K, Latif H, Vakiti A, Tefera E, Patel B, Fitzpatrick K.Adv Hematol. A 73-year-old man with coronary artery disease, hypertension, and renal insufficiency presents with recurrent, symptomatic atrial fibrillation. Amiodarone is among the most effective antiarrhythmic agents, but its use is associated with potentially serious toxic effects — is it right for this patient? Unable to load your delegates due to an error When long-term am… 2020 May 23;2020:3890706. doi: 10.1155/2020/3890706. Elsevier Science Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Information, resources, and support needed to approach rotations - and life as a resident.Valuable tools for building a rewarding career in health care.Information and tools for librarians about site license offerings.The authorized source of trusted medical research and education for the Chinese-language medical community.The most trusted, influential source of new medical knowledge and clinical best practices in the world. Epub 2018 Aug 20.Nazha B, Pandya B, Cohen J, Zhang M, Lopes RD, Garcia DA, Sherwood MW, Spyropoulos AC.Circulation. Amiodarone is recommended for rhythm control. Are you a member of an institution such as a university or hospital?No potential conflict of interest relevant to this article was reported.From the Division of Cardiology, Beth Israel Deaconess Medical Center, Boston.Address reprint requests to Dr. Zimetbaum at Beth Israel Deaconess Medical Center, 185 Pilgrim Rd., Boston, MA 02215, or at J Cardiol. 2019 Jan;54(1):73-80. doi: 10.1007/s10840-018-0427-y. Epub 2013 Jan 21.Boonyawat K, Caron F, Li A, Chai-Adisaksopha C, Lim W, Iorio A, Lopes RD, Garcia D, Crowther MA.J Thromb Haemost. Atrial fibrillation (AF) poses significant burden to patients, physicians, and healthcare systems globally. Unable to load your collection due to an error It results from irregular, disorganized electrical activity in the atria, leading to an irregular ventricular rhythm.