A dosing schedule based on the creatinine clearance, body weight and volume of distribution has been developed from pharmacokinetic data taken from the literature. Capreomycin: 15 mg/kg IV or IM per day: Use with caution in patients with renal insufficiency. Acta Med Scand 202: 437–433Lehmann HU, Witt E, Hochrein H (1978) Lebensbedrohliche Digitalisintoxikationen mit und ohne saluretische Zusatztherapie. (If given IVPush-admin over at least 5 min). Seek specialist advice for people who are elderly and who have renal impairment. Radioimmunoassayed serum concentration and urinary excretion data for digoxin from azotemic patients were characterized using a 2‐compartment open model. Georg Thieme, StuttgartDobbs SM, Mawer, GE, Rodgers EM, Woodcock BG (1976) Can digoxin dose requirements be predicted? with careful assessment of clinical response before each additional dose.Table 5: Usual Daily Maintenance Dose Requirements (mcg) of Digoxin for Estimated Peak Body Stores of 10 mcg/kgTable 6: Daily Maintenance Doses in Children with Normal Renal FunctionIt cannot be overemphasized that both adult and pediatric dosage guidelines provided are based upon average patient response and substantial individual variation can be expected. Additional fractions of this planned total dose may be given at 6 to 8-hour intervals, If the patient’s clinical response necessitates a change from the calculated loading dose of digoxin, then calculation of the maintenance dose should be based upon the amount actually given.A single initial dose of 500 to 750 mcg (0.5 to 0.75 mg) of digoxin tablets usually produces a detectable effect in 0.5 to 2 hours that becomes maximal in 2 to 6 hours.
Am J Med 64: 452–460Haasis R, Larbig D, Stunkat R, Bader H, Sebold H (1977) Radioimmunologische Bestimmung der Glykosidkonzentration im menschlichen Gewebe. Select one or more newsletters to continue. The Renal Drug Handbook is now available in database format.
Accordingly, ultimate dosage selection must be based upon clinical assessment of the patient.We comply with the HONcode standard for trustworthy health information - Ann Intern Med 77: 891–906Jusko WG, Weintraub M (1974) Myocardial distribution of digoxin and renal function.
Subscription will auto renew annually.Over 10 million scientific documents at your fingertips Maximal response from any maintenance dose of digoxin will be obtained when serum concentrations are at steady state and maximal body stores for that dose have been obtained. Dtsch Med Wochenschr 99: 1797–1803Peck CC, Sheiner LB, Martin CM, Combs DT, Melmon KL (1973) Computer-assisted digoxin therapy. Nephron 17: 161–187Gorry GA, Silverman H, Panker SG (1978) Capturing clinical expertise. For Adult.
Off dialysis. J Pharmacokinet Biopharm 2: 299–312Kramer WG, Kolibash AJ, Lewis RP, Bathala MS, Visconti JA, Reuning RG (1979) Pharmacokinetics of digoxin: Relationship between response intensitiy and predicted compartmental drug level in man. If pt has renal insufficiency give 6 to 10 mcg/kg IBW. Ann Intern Med 80: 516–519Evered DC, Chapman C (1970) Plasma digoxin concentrations and digoxin toxicity in hospital patients. In practice, this will mean that most patients will be maintained on 0.125 to 0.25mg digoxin daily, however, in those who show increased sensitivity to the adverse effects of digoxin, a dosage of 62.5microgram (0.0625mg) daily or less may suffice. J Clin Invest 49: 2377–2386Storstein O, Haustein V, Hatle L, Hillestad L, Storstein L (1977) Studies on digitalis XIII. Dtsch Med Wochenschr 104: 1243–1244Gault MH, Jeffrey JR, Chirito E, Ward LL (1976) Studies of digoxin dosage, kinetics and serum concentrations in renal failure and review of the literature. Available for Android and iOS devices. Br J Clin Pharmacol 3: 231–237Doherty JE (1973) The influence of renal function on digoxin metabolism. J Clin Pharmacol 14: 525–534Keller F, Blumenthal HP, Maertin K, Riebrock N (1977) Overall Pharmacokinetics during prolonged treatment of healthy volunteers with digoxin and Beta-methyl-digoxin. A computer program that considers clinical response to digitalis.
Klin Wochenschr 56: 503–517Sachs L (1974) Angewandte Statistik. J Pharmacokinet Biopharm 7: 47–61Landahl S, Lindblad B, Roupe S, Steen B, Svanborg A (1977) Digitalis therapy in a 70-year-old population. J Clin Pharmacol 18: 10–15Caldwell JH, Cline CT (1975) Biliary excretion of digoxin in man.
J Clin Pharmacol 13: 127–141Rietbrock N, Claren B, Keller F (1977) Glykosidkonzentrationen im Plasma bei standardisierter und arbiträrer Digitalisierung mit Digoxin und Beta-Acetyl-digoxin. Br Heart J 40: 177–183Oeff F, Maertin K, Kuhlmann J, Riebrock N (1977) Häufigkeit von Intoxikationszeichen nach Novodigal und Lanitop — eine prospektive Studie mit konstanten Dosen. Therefore, safe dosing of digoxin in renal insufficiency does not seem to be feasible in practice. Changing drug dosage regimens in renal insufficiency.