Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. I'm 28 and experiencing hormonal acne around my jaw area that I can't get rid of. Compare Kyleena vs Mirena head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Advise patients that insertion of Kyleena may be associated with pain and may precipitate a vasovagal response (fainting).Irregular bleeding and spotting are common in the first months following insertion of Kyleena. Mirena may also be used for purposes not listed in this medication guide. My acne has flared terribly, though. I now see an ENT and Neuro specialist. It does cause discomfort during intercourse **tmi** You’ll most likely have to find a certain position that doesn’t hurt you and stick with it every time. Prescribed for Birth Control.