A steady state will be achieved after five cycles of the drug half-life (T1/2ß), which is approximately 7 to 10 days in the average subject. Digoxin loading oral: 500-750mcg 2 doses 6 hours apart (max 1500mcg in 24 hours)
This calculator uses two different equations depending on the patient's comorbidities: 1. Slow digoxin loading — Slow oral digitalization, generally preferred for most patients, can be achieved by starting a maintenance dose of 0.125 to 0.25 mg daily. Monitoring: Obtain blood samples at least 4 hrs after IV dose and 6-8hrs after an oral dose. Based on these findings, the most recent ACC/AHA full guidelines recommend a digoxin concentration of 0.5 to 1 ng/mL.Note that in clinical practice, serum digoxin concentrations should be drawn at least 6 hours following oral digoxin administration to allow for drug distribution. In 1993, the PROVEDIn 1997, the Digitalis Investigation Group (DIG) trial was published,Following the publication of the DIG trial, a post-hoc analysis was published in 2003 examining the association of digoxin concentrations on the endpoints in the DIG trial.The clinical evidence support the theory that digoxin exerts a beneficial effect in heart failure via neurohormonal modulation at lower serum concentrations; however, it may exert a harmful effect via inotropic stimulation at higher serum concentrations. Additional doses of 125 to 375 mcg (0.125 to 0.375 mg) may be given cautiously at 6 to 8-hour intervals until clinical evidence of an adequate effect is noted. 2:39 Skip to 2 minutes and 39 seconds So how to give them? Serum levels: 0.5 to 2.0 ng/ml.
We comply with the HONcode standard for trustworthy health information - Applies to the following strengths: 250 mcg/mL (0.25 mg/mL); 50 mcg/mL (0.05 mg/mL); 100 mcg/mL (0.1 mg/mL); 125 mcg (0.125 mg); 250 mcg (0.25 mg); 500 mcg (0.5 mg); 50 mcg (0.05 mg); 100 mcg (0.1 mg); 200 mcg (0.2 mg); 62.5 mcg (0.0625 mg); 187.5 mcg (0.1875 mg)Total loading dose: Administer one-half the total loading dose initially (all formulations), then give one-fourth the total loading dose every 6 to 8 hours for two doses (IV and tablets), or give additional fractions every 4 to 8 hours (oral solution).Total loading dose: Administer one-half the total loading dose initially (all formulations), then give one-fourth the total loading dose every 6 to 8 hours for two doses (IV and tablets), or give additional fractions every 4 to 8 hours (oral solution).Total loading dose: Administer one-half the total loading dose initially (all formulations), then give one-fourth the total loading dose every 6 to 8 hours for two doses (IV and tablets), or give additional fractions every 4 to 8 hours (oral solution).For recommended maintenance doses according to lean body weight and renal function, the manufacturer product information should be consulted.This drug should be used at the lowest effective dose in order to achieve therapeutic efficacy and minimize side effects.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Therefore, when loading dose is equal to 603.2 microgram. Loading... A single initial dose of 500 to 750 mcg (0.5 to 0.75 mg) of digoxin tablets usually produces a detectable effect in 0.5 to 2 hours that becomes maximal in 2 to 6 hours. Press 'Calculate' to view calculation results. This nomogram, shown below, is specifically intended for a more appropriate digoxin concentration of 0.7 ng/mL and has been shown to be more accurate than the traditional Jellife or Koup and Jusko methods.Digitalis glycosides, like digoxin, have been used for more than 200 years to treat heart failure, but until recently, have had little clinical evidence to support their use in heart failure.
-Premature: IV: 15 to … Heart failure (without arrhythmias): Historically, the Jelliffe1 and Koup and Jusko2,3 methods have been commonly used; however, these equations target a higher digoxin concentration that may be inappropriate on the basis on the data from the Digitalis Investigation Group (DIG) post-hoc analysis.4 For this reason, this calculator is based on a newer equation and nomogram published by Bauman and DiDomenico,5 which … Predicted Css= (Dose) (0.65 to 0.8)/ Digoxin clearance. ClinCalc: