increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe
All drugs* listed below are covered for plans with the Essential Drug List. mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular
during pregnancy. 0000028500 00000 n
When
Turno tthe page pregnancy is detected, discontinue losartan as soon as possible. Other drugs may interact with hydrochlorothiazide and losartan, including prescription and over-the-counter medicines, vitamins, and herbal products.
and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart
AUC values for losartan, its active metabolite and hydrochlorothiazide, extrapolated from data obtained with losartan administered to rats at a dose of 50 mg/kg/day in combination with 12.5 mg/kg/day of hydrochlorothiazide, were approximately 6, 2, and 2 times greater than those achieved in humans with 100 mg of losartan in combination with 25 mg of hydrochlorothiazide.Losartan potassium was not carcinogenic when administered at maximally tolerated dosages to rats and mice for 105 and 92 weeks, respectively. Many patients will require more than 1 drug to achieve blood
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Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus General disorders and administration site conditions:Disease-associated Maternal and/or Embryo/Fetal RiskSkeletal muscle relaxants, nondepolarizing (e.g., tubocurarine)Corticosteroids, ACTH, or glycyrrhizin (found in liquorice)What is the most important information I should know about Hyzaar?Hyzaar has not been studied in children less than 18 years old.Tell your doctor about all your medical conditions including if you:Tell your doctor about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.If you have kidney problems, you may see a worsening in how well your kidneys work.A new or worsening condition called systemic lupus erythematosus (Lupus; SLE)Keep Hyzaar and all medicines out of the reach of children.losartan potassium and hydrochlorothiazide tablet, film coatedlosartan potassium and hydrochlorothiazide tablet, film coatedlosartan potassium and hydrochlorothiazide tablet, film coatedWe comply with the HONcode standard for trustworthy health information - examination of the first event of each type even if it was not the first event (e.g., a stroke following an
Revised: Oct 2018Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in
The Index provides an alphabetical list of all of the drugs included in this document. to mating and throughout gestation.Use of drugs that act on the renin-angiotensin system during the second and third trimesters of
In controlled clinical trials, discontinuation of therapy due to clinical adverse events was required
In addition to the active
If oligohydramnios is observed, discontinue Hyzaar, unless it is considered lifesaving for the mother. Fetal toxicity in rats, as evidenced by a slight increase in supernumerary ribs, was observed when females were treated prior to and throughout gestation with 10 mg/kg/day losartan in combination with 2.5 mg/kg/day hydrochlorothiazide. At baseline, 1195 (13%) had diabetes, 1326 (14%) had isolated systolic hypertension, 1469 (16%) had coronary heart disease, and 728 (8%) had cerebrovascular disease. 0000013742 00000 n
pressure response. At least 61 percent of the oral dose is eliminated unchanged within 24 hours. Table of contents. plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and
Respective AUCs for losartan, its active metabolite and hydrochlorothiazide at these dosages in rats were approximately 35, 10 and 10 times greater than those achieved in humans with the administration of 100 mg of losartan in combination with 25 mg hydrochlorothiazide. In this study, renal clearance was reduced by 55-85% for both losartan and its active metabolite in patients with mild or moderate renal insufficiency. Plasma concentrations of losartan and its active metabolite are similar in elderly and young hypertensives. days of therapy, and to report this symptom to a healthcare provider.
No overall differences in effectiveness were observed between these patients and younger patients. on page 3. As a result, a greater proportion of the patients on Hyzaar reached the target diastolic blood pressure (17.6% for Hyzaar, 9.4% for losartan; p=0.006). When pregnancy is detected, discontinue Hyzaar as soon as possible.Thiazides cross the placental barrier and appear in cord blood.
difference was primarily the result of an effect on fatal and nonfatal stroke. 0000012352 00000 n
Monitor serum electrolytes periodically [see Drug Interactions (7.1)] . groups were consistent between Black and non-Black patients. It is used to:Hyzaar and certain other medicines may interact with each other. than 30 mL/min. DOSAGE AND ADMINISTRATION Hypertension. The mechanism of the antihypertensive effect of thiazides is unknown.Losartan inhibits the pressor effect of angiotensin II (as well as angiotensin I) infusions.
yellow No. hypertrophy, but there is evidence that this benefit does not apply to Black patients. Here are some commonly asked questions and answers about how the drug list works with your prescription drug plan.