Key facts. If a patient treated with diclofenac sodium topical gel has any signs or symptoms of anemia, monitor hemoglobin or hematocrit.NSAIDs, including diclofenac sodium topical gel, may increase the risk of bleeding events. Does Clozapine ODT Interact with other Medications? If it is near the time of the next dose, skip the missed dose. To use the topical solution: Use this medicine exactly as directed by your doctor.
The following information includes only the average doses of this medicine. Most postmarketing reports of fatal GI events occurred in elderly or debilitated patients. Data from observational studies regarding potential embryofetal risks of NSAID use in women in the first or second trimesters of pregnancy are inconclusive. Do not use combination therapy with diclofenac sodium topical gel and an oral NSAID unless the benefit outweighs the risk.The following adverse reactions are discussed in greater detail in other sections of the labeling:Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.During clinical development, 913 patients were exposed to diclofenac sodium topical gel in randomized, double-blind, multicenter, vehicle-controlled, parallel-group studies in osteoarthritis of the superficial joints of the extremities.
Do not increase your dose, use it more often than prescribed, or apply the medication to any area not prescribed by your doctor.If you are using this drug "as needed" (not on a regular schedule), remember that pain Tell your doctor right away if you have any serious side effects, including: signs of This drug may rarely cause serious (possibly fatal) This is not a complete list of possible side effects. Sprains, Strains?
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Diclofenac sodium topical gel should be gently massaged into the skin ensuring application to the entire affected hand, wrist, or elbow. Do not apply more than 16 grams of diclofenac per day to any single joint of the lower body (such as Discuss the risks and benefits of using this drug with your doctor or pharmacist. * WOMAC = Western Ontario McMaster Osteoarthritis Index.† Difference is adjusted using an analysis of covariance (ANCOVA) model with main effects of treatment and center and baseline covariate.‡ Difference is adjusted using an analysis of covariance (ANCOVA) model with main effects of treatment, center, indicator of pain in the CMC-1joint, and baseline as a covariate, and the treatment-by-CMC-1 strata.Diclofenac sodium topical gel, 1% is an opaque white gel and is available in tubes containing 100 grams of the topical gel in each tube. Diclofenac Gel Description. A second group of 14 patients with maturity onset diabetes well controlled by a standard diet and tolbutamide (Rastinon) was examined for a … Abnormal tests occurred during the first 2 months of therapy with diclofenac in 42 of the 51 patients in all trials who developed marked transaminase elevations.In postmarketing reports, cases of drug-induced hepatotoxicity have been reported in the first month, and in some cases, the first 2 months of therapy, but can occur at any time during treatment with diclofenac.
Its molecular formula is C 14 H 10 Cl 2 NNaO 2, and it has the following chemical structure: The concurrent use of aspirin and an NSAID, such as diclofenac, increases the risk of serious gastrointestinal (GI) events [Two large, controlled clinical trials of a COX-2 selective NSAID for the treatment of pain in the first 10-14 days following CABG surgery found an increased incidence of myocardial infarction and stroke. Take diclofenac tablets or capsules with a meal or snack, or just after eating. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3-6 months, and in about 2%-4% of patients treated for one year. Exercise caution when prescribing diclofenac sodium topical gel with concomitant drugs that are known to be potentially hepatotoxic (e.g., acetaminophen, antibiotics, anti-epileptics).NSAIDs, including diclofenac sodium topical gel, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. Although not all of these side effects may occur, if they do occur they may need medical attention. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Keep using this medicine for the full time of treatment.
Inform patients about the signs and symptoms of serious skin reactions, and to discontinue the use of diclofenac sodium topical gel at the first appearance of skin rash or any other sign of hypersensitivity.